REGIONAL RESPIRATORY CLEARANCE OF AEROSOLIZED TC-99M-DTPA - POSTURE AND SMOKING EFFECTS
REGIONAL RESPIRATORY CLEARANCE OF AEROSOLIZED TC-99M-DTPA - POSTURE AND SMOKING EFFECTS
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DOI：
10.1152/jappl.1986.60.6.2000
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发表时间：
1986-06-01
影响因子：
3.3
通讯作者：
HUCHON, GJ
中科院分区：
文献类型：
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作者：
DUSSER, DJ;MINTY, BD;HUCHON, GJ
本研究以10名健康非吸烟者和8名健康吸烟者为研究对象，分别采用直立和平卧睡姿，探讨区域内对锝-99m标记的二乙烯三胺五乙酸99mTc-DTPA （RC-DTPA）的呼吸清除率是否存在差异，并评估姿势和吸烟对区域内RC-DTPA的影响。通过雾化99mTc-DTPA （0.8 .mu）的肺清除率（%/min）评估RC-DTPA。米多;2.4 GSD)，使用校正了再循环放射性的数据，在肺后野的上部（1区）、中部（2区）和下部（3区）。在非吸烟者中，1区RD-DTPA在直立（P < 0.001）和仰卧位（P < 0.01）均快于2区和3区。姿态变化对区域RC-DTPA无影响。在吸烟者中，与不吸烟者相比，所有区域的RC-DTPA均升高（P = 0.004），直立姿势时1区RC-DTP与其他区域相比进一步升高（P < 0.001）。结果表明：1)非吸烟区1区RC-DTPA比其他区快，这与放射性再循环无关；2)体态不改变非吸烟者的区域RC-DTPA；3)吸烟增加了所有区域的RC-DTPA，直立位置1区域的RC-DTPA增加更多。
We studied 10 healthy nonsmokers and 8 healthy smokers, in both the upright and supine position, to investigate whether regional differences in respiratory clearance of technetium-99m-labeled diethylenetriamine pentaacetic acid 99mTc-DTPA (RC-DTPA) existed and to assess the influence of posture and smoking on the regional RC-DTPA. RC-DTPA was assessed by the lung clearance rates (%/min) of aerosolized 99mTc-DTPA (0.8 .mu.m MMD; 2.4 GSD), using data corrected for recirculating radioactivity, in the upper (zone 1), a middle (zone 2), and lower (zone 3) posterior lung fields. In nonsmokers, RD-DTPA in zone 1 was faster than in zone 2 or 3 in both the upright (P < 0.001) and supine positions (P < 0.01). Noneffect was produced by changes in posture on the regional RC-DTPA. In smokers, RC-DTPA was increased in all zones compared with the nonsmokers (P = 0.004), with a further increase in RC-DTP in zone 1 in the upright posture compared with the other regions (P < 0.001). We conclude that 1) in nonsmoker regional RC-DTPA is faster in zone 1 than in other zones, and this is not related to recirculation of radioactivity; 2) posture does not modify the regional RC-DTPA of nonsmokers; 3) smoking increases RC-DTPA in all zones and more in zone 1 in the upright position.