Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog.
Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog.
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并发肾淀粉样变性和胸腺瘤导致狗致命的心室血栓。
DOI：
10.1111/jvim.15062
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发表时间：
2018
影响因子：
2.6
通讯作者：
LeVine,DanaN
中科院分区：
文献类型：
--
作者：
Loewen,JenniferM;Cianciolo,RachelE;Zhang,Liwen;Yaeger,Michael;Ward,JessicaL;Smith,JodiD;LeVine,DanaN
与胸腺瘤相关的肾病在人身上有报道，但在狗身上没有报道。在这份报告中，我们描述了一只患有胸腺瘤和并发肾淀粉样变性的狗。一例7岁被去势的雄性Weimaraner因进行性厌食、嗜睡和呼吸急促而被提出。这只狗被诊断为氮质血症，明显的蛋白尿，以及胸腺瘤，已通过手术切除。手术后，这只狗出现了很大的左室血栓，并被安乐死。尸检证实存在左室血栓，组织病理学检查显示肾脏淀粉样变性。我们推测肾脏淀粉样变性继发于胸腺瘤，淀粉样变性依次导致肾病综合征、高凝状态和脑室血栓形成。这一病例说明了胸腺瘤相关肾病可能发生在狗身上，怀疑患有胸腺瘤的狗应该进行尿液分析和尿蛋白肌酐比率，作为手术前数据库的一部分。
Thymoma‐associated nephropathies have been reported in people but not in dogs. In this report, we describe a dog with thymoma and concurrent renal amyloidosis. A 7‐year‐old castrated male Weimaraner was presented for progressive anorexia, lethargy, and tachypnea. The dog was diagnosed with azotemia, marked proteinuria, and a thymoma that was surgically removed. Postoperatively, the dog developed a large left ventricular thrombus and was euthanized. Necropsy confirmed the presence of a left ventricular thrombus and histopathology revealed renal amyloidosis. We speculate that the renal amyloidosis occurred secondary to the thymoma, with amyloidosis in turn leading to nephrotic syndrome, hypercoagulability, and ventricular thrombosis. This case illustrates the potential for thymoma‐associated nephropathies to occur in dogs and that dogs suspected to have thymoma should have a urinalysis and urine protein creatinine ratio performed as part of the pre‐surgical database.