Membrane phospholipid asymmetry: Host response to the externalization of phosphatidylserine
Membrane phospholipid asymmetry: Host response to the externalization of phosphatidylserine
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DOI：
10.1002/jlb.59.6.784
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发表时间：
1996-06-01
影响因子：
5.5
通讯作者：
Schroit, AJ
中科院分区：
文献类型：
--
作者：
Bruckheimer, EM;Schroit, AJ
膜磷脂不对称是调节细胞功能和动态平衡的重要因素。脂类转运蛋白的活性对细胞寿命中膜脂成分的调节起着重要作用。这些蛋白活性的改变导致磷脂酰丝氨酸移动到细胞的外叶，这促进了一些生理反应，包括启动凝血级联反应和网状内皮系统对细胞的识别。
Membrane phospholipid asymmetry is an important regulator of cellular function and homeostasis. The activities of lipid transporters are contributing factors to the regulation of membrane lipid composition over the Lifespan of the cell. Alterations in the activites of these proteins result in the movement of phosphatidylserine to the cell's outer leaflet, This promotes several physiologic responses including initiation of the coagulation cascade and cell recognition by the reticuloendothelial system.