A NEW TEMPERATURE-RESPONSIVE AND PH-RESPONSIVE COPOLYMER FOR POSSIBLE USE IN PROTEIN CONJUGATION
A NEW TEMPERATURE-RESPONSIVE AND PH-RESPONSIVE COPOLYMER FOR POSSIBLE USE IN PROTEIN CONJUGATION
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DOI：
10.1002/macp.1995.021960424
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发表时间：
1995-04-01
影响因子：
2.5
通讯作者：
HOFFMAN, AS
中科院分区：
文献类型：
--
作者：
CHEN, GH;HOFFMAN, AS
合成了n -异丙基丙烯酰胺（NIPAAm）与4-戊烯酸（PAc）的温度敏感和ph敏感共聚物，并对其单体反应性进行了估计。研究了聚合物组成、pH和水溶液离子强度对共聚物低临界溶液温度的影响。结果表明，与聚n -异丙基丙烯酰胺的LCST相比，这些共聚物的LCST可以通过改变pH值而降低或提高。
The temperature- and pH-sensitive copolymers of N-isopropylacrylamide (NIPAAm) with 4-pentenoic acid (PAc) were synthesized and the monomer reactivity ratios were estimated. The effects of polymer composition, pH and ionic strength of the aqueous solution on the lower critical solution temperature (LCST) of the copolymers were investigated. It was found that the LCSTs of these unusual copolymers can be either lowered or raised compared to the LCST of poly(N-isopropylacrylamide) by changing the pH.