An Updated View on the Rck Invasin of Salmonella: Still Much to Discover.
An Updated View on the Rck Invasin of Salmonella: Still Much to Discover.
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DOI：
10.3389/fcimb.2017.00500
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发表时间：
2017
影响因子：
5.7
通讯作者：
Wiedemann A
中科院分区：
文献类型：
--
作者：
Mambu J;Virlogeux-Payant I;Holbert S;Grépinet O;Velge P;Wiedemann A
沙门氏菌是一种兼性细胞内革兰氏阴性细菌，根据宿主和血清型，引起从胃肠炎到伤寒的各种食源性和水源性疾病。因此，沙门氏菌是对公共卫生的主要威胁。沙门氏菌致病的关键步骤是吞噬和非吞噬宿主细胞的入侵。为了触发自身内化到非吞噬细胞中，沙门氏菌已经开发了不同的机制，涉及几种入侵因子。几十年来，人们认为沙门氏菌只能通过一种称为T3 SS-1的第三型分泌系统进入细胞。最近的研究表明，这种细菌表达外膜蛋白，如Rck蛋白，它能够诱导沙门氏菌进入机制。Rck模拟天然宿主细胞配体，通过与表皮生长因子受体相互作用触发细菌的吞噬。因此，沙门氏菌能够在沙门氏菌感染过程中使用多种进入途径。然而，目前尚不清楚沙门氏菌如何以及何时利用T3 SS-1和Rck进入机制。由于一系列的评论都集中在T3 SS-1，这篇评论的目的是描述目前的知识和我们的理解Rck外膜蛋白的局限性。本文综述了Rck表达的调控级联反应和Rck介导的细胞侵袭的分子机制。RCK介导的入侵沙门氏菌的发病机制和沙门氏菌RCK依赖的进入后的细菌的细胞内行为的潜在作用进行了讨论。
Salmonella is a facultative intracellular Gram-negative bacterium, responsible for a wide range of food- and water-borne diseases ranging from gastroenteritis to typhoid fever depending on hosts and serotypes. Salmonella thus represents a major threat to public health. A key step in Salmonella pathogenesis is the invasion of phagocytic and non-phagocytic host cells. To trigger its own internalization into non-phagocytic cells, Salmonella has developed different mechanisms, involving several invasion factors. For decades, it was accepted that Salmonella could only enter cells through a type three secretion system, called T3SS-1. Recent research has shown that this bacterium expresses outer membrane proteins, such as the Rck protein, which is able to induce Salmonella entry mechanism. Rck mimics natural host cell ligands and triggers engulfment of the bacterium by interacting with the epidermal growth factor receptor. Salmonella is thus able to use multiple entry pathways during the Salmonella infection process. However, it is unclear how and when Salmonella exploits the T3SS-1 and Rck entry mechanisms. As a series of reviews have focused on the T3SS-1, this review aims to describe the current knowledge and the limitations of our understanding of the Rck outer membrane protein. The regulatory cascade which controls Rck expression and the molecular mechanisms underlying Rck-mediated invasion into cells are summarized. The potential role of Rck-mediated invasion in Salmonella pathogenesis and the intracellular behavior of the bacteria following a Salmonella Rck-dependent entry are discussed.
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影响因子：
6.7
作者：
Finn CE;Chong A;Cooper KG;Starr T;Steele-Mortimer O
通讯作者：
Steele-Mortimer O
影响因子：
3.1
作者：
Cirillo, DM;Heffernan, EJ;Guiney, DG
通讯作者：
Guiney, DG
影响因子：
3.1
作者：
Chausse, Anne-Marie;Grepinet, Olivier;Velge, Philippe
通讯作者：
Velge, Philippe
影响因子：
3.2
作者：
Bouwman, CW;Kohli, M;Martin, NL
通讯作者：
Martin, NL
DOI：
10.3390/molecules20011134
发表时间：
2015-01-12
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Barlag B;Hensel M
通讯作者：
Hensel M