Synergistic interaction of testosterone and oestradiol inhibits permatogenesis in rats
Synergistic interaction of testosterone and oestradiol inhibits permatogenesis in rats
复制标题
睾酮和雌二醇的协同相互作用抑制大鼠的生殖发生
作者：
L. Ewing;C. Desjardins;D. Irby;B. Robaire
男性避孕的一种实验方法是全身施用雄激素类固醇，但治疗有时无法诱发无精症1-4。为了克服这一困难，我们对雄激素-孕激素制剂进行了测试，但它们并没有完全抑制所有接受治疗的男性的精子发生5-8。我们认为这种可变的反应可能是由于雄激素和孕激素的抗促性腺激素活性相对较弱以及难以精确控制类固醇的剂量。我们推断，如果以相对恒定的速度连续施用类固醇，并且如果用更有效的垂体促性腺激素分泌抑制剂取代孕激素，则每个男性都可能出现无精症。我们在这里描述了通过皮下缓释装置对成年雄性大鼠施用睾酮-雌二醇制剂的功效测试结果。使用雌二醇是因为，与睾酮一样，它是哺乳动物睾丸分泌的天然类固醇9-13，并且是垂体促性腺激素分泌的有效抑制剂14-16。
ONE experimental approach to male contraception has been the systemic administration of androgenic steroids, but treatment has failed sometimes to induce azoospermia1–4. To overcome this difficulty, androgen–progestin formulations have been tested, but they did not inhibit spermatogenesis completely in all treated men5–8. We thought that this variable response was probably due to the relatively weak anti-gonadotropic activity of both androgens and progestins and the difficulty of controlling precisely the dose of steroids administered. We reasoned that azoospermia might be achieved in every male if steroids were administered continuously and at relatively constant rates and if progestins were replaced by a more potent inhibitor of pituitary gonadotropin secretion. We describe here the results of a test of the efficacy of testosterone–oestradiol formulations administered to adult male rats by means of a subdermal sustained release device. Oestradiol was used because, like testosterone, it is a naturally occurring steroid secreted by the mammalian testis9–13 and because it is a potent inhibitor of pituitary gonadotropin secretion14–16.