Fecal Markers: Calprotectin and Lactoferrin
Fecal Markers: Calprotectin and Lactoferrin
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DOI：
10.1016/j.gtc.2012.01.007
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发表时间：
2012-06-01
影响因子：
3.7
通讯作者：
Kane, Sunanda
中科院分区：
文献类型：
--
作者：
Abraham, Bincy P.;Kane, Sunanda
非特异性胃肠道症状在炎症性和非炎症性两种情况下都存在。非侵入性诊断工具包括粪便标志物、钙保护素和乳铁蛋白。这些是稳定的蛋白质，存在于活动性和慢性炎症患者的粪便中。研究表明，它们能够以可重复的方式识别炎症的存在，并与内窥镜检查结果有很好的相关性。这些标记物也可以用来预测疾病爆发以及监测治疗的成功。无创粪便标记物是一种方便、可靠的临床工具，可用于临床实践。
Nonspecific gastrointestinal symptoms are present in both inflammatory and noninflammatory conditions. Noninvasive diagnostic tools include the fecal markers, calprotectin and lactoferrin. These are stable proteins that are present in the stool of patients with active and chronic inflammation. Studies have shown their ability to discriminate in a reproducible fashion the presence of inflammation with excellent correlation to endoscopic findings. These markers can also be used for predicting a disease flare as well as monitoring the success of treatment. Noninvasive stool markers are a convenient and reliable clinical tool that can be used in clinical practice.