Overexpression of UHRF1 and its potential role in the development of invasive ductal breast cancer validated by integrative bioinformatics and immunohistochemistry analyses.
Overexpression of UHRF1 and its potential role in the development of invasive ductal breast cancer validated by integrative bioinformatics and immunohistochemistry analyses.
复制标题
通过综合生物信息学和免疫组织化学分析验证 UHRF1 的过度表达及其在浸润性导管乳腺癌发展中的潜在作用
DOI：
10.21037/tcr.2019.06.19
复制
发表时间：
2019-08
影响因子：
0.9
通讯作者：
Ying Y
中科院分区：
文献类型：
--
作者：
Yang Y;Liu G;Qin L;Ye L;Zhu F;Ying Y
越来越多的证据表明泛素样PHD和含环指结构域蛋白1（UHRF 1）在包括肝细胞癌、胰腺癌和膀胱癌在内的癌症发展中的作用。然而，UHRF1与乳腺癌之间的相关性仍不清楚。本研究旨在通过整合多水平表达数据和免疫组化分析，分析UHRF 1的表达及其在浸润性导管乳腺癌（IDC）发展中的作用。方法利用GEO和TCGA数据库收集IDC中UHRF 1的表达数据。同时采用免疫组化方法分析UHRF1表达与IDC临床特征的关系。结果GEO和TCGA数据库均显示UHRF1在IDC中表达上调。免疫组化结果显示，UHRF 1在IDC组织中明显过表达，其表达水平从导管原位癌到IDC呈逐渐增高趋势。值得注意的是，UHRF 1水平升高与雌激素受体表达、病理分级和疾病预后密切相关。此外，UHRF 1高表达的患者预后较差。结论UHRF 1在乳腺癌的发生发展中起促进作用，UHRF 1的过表达可作为乳腺癌浸润性导管癌预后的生物标志物。
Background Increasing evidence has highlighted the role of ubiquitin-like PHD and RING finger domain-containing protein 1 (UHRF1) in the development of cancers, including hepatocellular carcinoma, pancreatic cancer, and bladder cancer. However, the correlation between UHRF1 and breast cancer remains unclear. The present study aimed to analyze the expression of UHRF1 and its role in the development of invasive ductal breast cancer (IDC) by integrating multilevel expression data and immunohistochemistry analysis. Methods The Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were used to gather UHRF1 expression data on IDC. Additionally, immunohistochemistry analysis was used to investigate the correlations between UHRF1 expression and the clinical characteristics of IDC. Results The GEO and TCGA databases indicated that UHRF1 was up-regulated in IDC. Consistently, the immunohistochemical specimens showed that the significant overexpression of UHRF1 in IDC, and its expression level showed an increasing trend from ductal carcinomas in situ to IDC. Notably, the increased levels of UHRF1 were closely correlated with estrogen receptor expression, pathological grade, and the prognosis of the disease. In addition, patients with a high UHRF1 expression had a poorer prognosis. Conclusions In conclusion, our findings suggested that UHRF1 plays a promoting role in breast tumorigenesis, and the over-expression of UHRF1 could serve as a biomarker for the prognosis in invasive ductal carcinomas in breast cancer.
登录
查看更多内容
影响因子：
11.2
作者：
McDonnell DP;Park S;Goulet MT;Jasper J;Wardell SE;Chang CY;Norris JD;Guyton JR;Nelson ER
通讯作者：
Nelson ER
影响因子：
2.1
作者：
Parise, Carol A.;Bauer, Katrina R.;Caggiano, Vincent
通讯作者：
Caggiano, Vincent
影响因子：
254.7
作者：
DeSantis, Carol;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
针对泛素蛋白样，博士学位和含环的1（UHRF1）的集合和环相关（SRA）结构域，以进行抗癌药物开发。
影响因子：
--
作者：
Patnaik D;Estève PO;Pradhan S
通讯作者：
Pradhan S
影响因子：
3.8
作者：
Chen, Dung-Tsa;Nasir, Aejaz;Culhane, Aedin;Venkataramu, Chinnambally;Fulp, William;Rubio, Renee;Wang, Tao;Agrawal, Deepak;McCarthy, Susan M.;Gruidl, Mike;Bloom, Gregory;Anderson, Tove;White, Joe;Quackenbush, John;Yeatman, Timothy
通讯作者：
Yeatman, Timothy