Effect of ginseng saponins on cholesterol metabolism. I. The level and the synthesis of serum and liver cholesterol in rats treated with ginsenosides.
Effect of ginseng saponins on cholesterol metabolism. I. The level and the synthesis of serum and liver cholesterol in rats treated with ginsenosides.
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人参皂苷对胆固醇代谢的影响。
DOI：
10.1248/cpb.23.1009
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发表时间：
1975
影响因子：
1.7
通讯作者：
J. Shoji
中科院分区：
文献类型：
--
作者：
K. Sakakibara;Y. Shibata;T. Higashi;S. Sanada;J. Shoji
研究了从人参（Panax ginseng C.A. MEYER 的根）中纯化的人参皂苷-Rb1、-Rc、-Rd、-Re 和-Rg1 对胆固醇代谢的体内影响。向大鼠腹腔注射各5mg纯人参皂苷4小时后，测定血清和肝脏胆固醇的浓度以及血清和肝脏胆固醇中14C-乙酸的掺入量。结果表明，施用皂苷可增强胆固醇生物合成，特别是人参皂苷-Rb1（人参皂苷的主要成分）。
The in vivo effect on cholesterol metabolism of ginsenoside-Rb1, -Rc, -Rd, -Re, and -Rg1 purified from Ginseng (the root of Panax ginseng C.A. MEYER) was investigated. Four hours after the intraperitoneal injection of 5 mg of each pure ginsenoside into rats, the concentrations of serum and liver cholesterol and the incorporation of 14C-acetate into serum and liver cholesterol were determined. The results indicated the enhancement of cholesterol biosynthesis by administered saponins, particularly by ginsenoside-Rb1, a predominant component of Ginseng saponins.