Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome
Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome
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DOI：
10.1016/j.metabol.2011.03.002
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发表时间：
2011-10-01
影响因子：
9.8
通讯作者：
Ho, Clement K. M.
中科院分区：
文献类型：
--
作者：
Li, Hang Wun Raymond;Brereton, Rebecca E.;Ho, Clement K. M.
维生素D缺乏和多囊卵巢综合征（PCOS）都与代谢综合征的某些方面有关，但目前尚不清楚维生素D缺乏是否会导致多囊卵巢综合征女性中常见的代谢紊乱。本研究旨在调查(1)苏格兰多囊卵巢综合征妇女维生素D缺乏症的患病率(2)维生素D状况与代谢危险因素之间的关系。这是一项对52名妇女（PCOS组25名，对照组27名）的观察性研究。血清25-羟基维生素D浓度低于25 nmol/L属于严重维生素D缺乏症，PCOS组和对照组分别有44.0%和11.2%的受试者存在严重维生素D缺乏症（P = 0.047）。在PCOS患者中，25-羟基维生素D浓度与体重指数（P = 0.033）、c反应蛋白（P = 0.027）、游离雄激素指数（P = 0.025）呈负相关，与定量胰岛素敏感性检查指数（P = 0.035）、高密度脂蛋白胆固醇（P = 0.033）、性激素结合球蛋白（P = 0.038）呈正相关。维生素D缺乏与定量胰岛素敏感性检查指数和HDL-C的关系与体重指数和腰臀比无关。维生素D缺乏症在苏格兰多囊卵巢综合征女性中非常普遍，多囊卵巢综合征患者中维生素D缺乏症的比例高于对照组女性。我们还证明了多囊卵巢综合征患者维生素D状态与胰岛素敏感性、HDL-C和c反应蛋白的相关性，这支持了维生素D缺乏与多囊卵巢综合征女性多种代谢危险因素相关的越来越多的证据。(C) 2011爱思唯尔公司版权所有。
Both vitamin D deficiency and polycystic ovary syndrome (PCOS) are associated with aspects of metabolic syndrome, but it is unclear whether vitamin D deficiency contributes to the metabolic disturbances commonly found in women with PCOS. This study sought to investigate (1) the prevalence of vitamin D deficiency in PCOS women in Scotland and (2) the relationship between vitamin D status and metabolic risk factors. This was an observational study on 52 women (25 in PCOS group and 27 in control group). Serum 25-hydroxyvitamin D concentrations less than 25 nmol/L were classified as severe vitamin D deficiency and were found in 44.0% and 11.2% of subjects in the PCOS and control groups, respectively (P = .047). Among the PCOS subjects, 25-hydroxyvitamin D concentrations were negatively correlated with body mass index (P = .033), C-reactive protein (P = .027), and free androgen index (P = .025) and positively correlated with quantitative insulin sensitivity check index (P = .035), high-density lipoprotein cholesterol (HDL-C) (P = .033), and sex hormone binding globulin (P = .038). Associations of vitamin D deficiency with quantitative insulin sensitivity check index and HDL-C were independent of body mass index and waist-to-hip ratio. Vitamin D deficiency is highly prevalent in PCOS women in Scotland, and a larger proportion of PCOS patients than control women were found to be vitamin D deficient. We also demonstrate correlations of vitamin D status with insulin sensitivity, HDL-C, and C-reactive protein in PCOS patients, which support the increasing evidence that vitamin D deficiency is associated with multiple metabolic risk factors in PCOS women. (C) 2011 Elsevier Inc. All rights reserved.