A history of iron deficiency anemia during infancy alters brain monoamine activity later in juvenile monkeys.
A history of iron deficiency anemia during infancy alters brain monoamine activity later in juvenile monkeys.
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DOI：
10.1002/dev.20365
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发表时间：
2009-04-01
影响因子：
2.2
通讯作者：
Beard, John L
中科院分区：
文献类型：
--
作者：
Coe, Christopher L;Lubach, Gabriele R;Beard, John L
无论是在缺铁期间还是缺铁后，依赖铁的神经过程都会受到影响，这引起了人们的潜在担忧，即许多成长中的婴儿普遍经历的贫血可能会对发育中的大脑产生长期影响。为了进一步研究ID对未成熟大脑的影响，研究人员在49只猕猴出生后的第一年对其进行了评估。这些母亲和断奶后的婴儿被维持在含有180毫克/公斤铁的标准饮食中，并且没有提供其他富含铁的食物作为奖励或补充。随着婴儿的成长，他们都接受了血液学检查，其中16名（33.3%）在4到8个月大的时候出现了明显的ID。在此贫血期和随后的1岁时，收集脑脊液（CSF）标本，比较缺铁婴儿和缺铁婴儿的单胺活性。单胺类神经递质和代谢物水平在4个月和8个月大时是正常的，但到1岁时，以前贫血的猴子的多巴胺水平明显降低，去甲肾上腺素水平明显升高。这些发现表明，ID可以影响这两个重要的神经递质系统的发育轨迹，这两个系统与情绪和行为表现有关，并且在幼龄猴子的恢复期间影响最为明显。
Both during and after a period of iron deficiency (ID), iron-dependent neural processes are affected, which raises the potential concern that the anemia commonly experienced by many growing infants could have a protracted effect on the developing brain. To further investigate the effects of ID on the immature brain, 49 infant rhesus monkeys were evaluated across the first year of life. The mothers, and subsequently the infants after weaning, were maintained on a standardized diet containing 180 mg/kg of iron and were not provided other iron-rich foods as treats or supplements. As the infants grew, they were all screened with hematological tests, which documented that 16 (33.3%) became markedly ID between 4 and 8 months of age. During this anemic period and subsequently at 1 year of age, cerebrospinal fluid (CSF) specimens were collected to compare monoamine activity in the ID and iron-sufficient infants. Monoamine neurotransmitters and metabolite levels were normal at 4 and 8 months of age, but by 1 year the formerly anemic monkeys had significantly lower dopamine and significantly higher norepinephrine levels. These findings indicate that ID can affect the developmental trajectory of these two important neurotransmitter systems, which are associated with emotionality and behavioral performance, and further that the impact in the young monkey was most evident during the period of recovery.