Stress induces rapid changes in serotonergic activity: restraint and exertion
Stress induces rapid changes in serotonergic activity: restraint and exertion
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DOI：
10.1016/s0166-4328(00)00143-1
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发表时间：
2000-06-15
影响因子：
2.7
通讯作者：
Summers, CH
中科院分区：
文献类型：
--
作者：
Emerson, AJ;Kappenman, DP;Summers, CH
中枢血清素能系统的快速激活发生在对优势蜥蜴攻击的社会压力的反应中。5 -羟色胺能活性的快速表达发生在伏隔核、海马和脑干。为了比较先前测量的由社会压力诱发的反应和由身体压力引起的反应，在约束压力（处理）和强迫身体运动后检测了血清素能活性。处理后，一些雄性卡罗来纳山羊被放置在跑道上，在1分钟或一半的时间内奔跑直到没有动静。对照组不经治疗就死亡。受到处理压力的蜥蜴纹状体、背皮质、蓝核和伏隔核的血清素活性（5-HIAA/5-HT）迅速（25秒）增加。应激引起的血清素系统的其他变化发生在中缝和海马体。处理应激引起的血清素能变化可通过运动（至最大运动时间的50%）逆转枕下、纹状体和伏隔核。蜥蜴的海马体、枕下、纹状体、杏仁核内侧、蓝斑、后脑区和中脑的血清素能分布在对刺激不再有反应之前（最大运动时间）与更剧烈运动时显著不同。生理应激（处理）通过在海马体、枕下、伏隔核和蓝核中产生快速的血清素能变化来模拟社会应激。与此相反，内侧杏仁核，先前被证明只有在一段时间延迟后才能对社会压力产生血清素的反应，并没有对约束压力表现出快速反应。(C) 2000 Elsevier Science B.V.版权所有
Rapid activation of central serotonergic systems occurs in response to the social stress of aggression in dominant lizards. The most rapid expression of serotonergic activity occurs in nucleus accumbens, hippocampus and brainstem. To compare previously measured responses induced by social stressors with those provoked by physical stress, serotonergic activity was examined following restraint stress (handling) and forced physical exertion. After handling, some male Anolis carolinensis were placed on a race track and either run until there was no movement following 1 min of prodding, or half that time. Controls were killed without treatment. Lizards stressed by handling showed rapid (25 s) increases in serotonergic activity (5-HIAA/5-HT) in striatum, dorsal cortex, locus ceruleus, and nucleus accumbens. Other changes in serotonergic systems caused by stress occurred in raphe and hippocampus. serotonergic changes induced by handling stress were reversed by exercise (to 50% maximal exertion time) in subiculum, striatum and nucleus accumbens. The serotonergic profile of lizards run until they would no longer respond to prodding (maximal exertion time) was significantly different from that for more acute exertion in hippocampus, subiculum, striatum, medial amygdala, locus ceruleus, area postrema, and raphe. Physical stress (handling) mimicked social stress by producing rapid serotonergic changes in hippocampus, subiculum, nucleus accumbens and locus ceruleus. In contrast, the medial amygdala, which has previously been demonstrated to respond serotonergically to social stress only after a temporal delay, did not show a rapid response to restraint stress. (C) 2000 Elsevier Science B.V. All rights reserved.