Hematological and serum biochemical values in cynomolgus monkeys anesthetized with ketamine hydrochloride
Hematological and serum biochemical values in cynomolgus monkeys anesthetized with ketamine hydrochloride
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DOI：
10.1111/j.1600-0684.2005.00097.x
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发表时间：
2005-04-01
影响因子：
0.7
通讯作者：
Han, SS
中科院分区：
文献类型：
--
作者：
Kim, CY;Lee, HS;Han, SS
在19只雄性和15只雌性食蟹猴中研究了氯胺酮麻醉对血液学和血清生化变量的影响。在肌肉注射盐酸氯胺酮（10 mg/kg）后30分钟内，从头静脉采集血样。氯胺酮麻醉导致白细胞计数减少和淋巴细胞百分比显著降低。氯胺酮麻醉还使血清谷草转氨酶（AST）、丙氨酸转氨酶（ALT）和肌酸磷酸激酶（CPK）活性升高，而使血清葡萄糖、无机磷、钠和钾浓度降低。血液学和血清生化值的变化将进行讨论。在设计食蟹猴研究和解释食蟹猴数据时，应考虑这些变化。
The effects of ketamine anesthesia on both hematological and serum biochemical variables were investigated in 19 male and 15 female cynomolgus monkeys. Blood samples were obtained from the cephalic vein within 30 minutes of an intramuscular injection of ketamine hydrochloride (10 mg/kg). Ketamine anesthesia caused a reduction in leukocyte counts and a significant reduction in lymphocytes percentages. Ketamine anesthesia also increased the serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatine phosphokinase (CPK), but reduced the serum concentrations of glucose, inorganic phosphate, sodium and potassium. The alterations of hematological and serum biochemical values will be discussed. These alterations should be considered when designing studies for and interpreting data from cynomolgus monkeys.