EXTRACELLULAR ION CONCENTRATIONS DURING SPREADING DEPRESSION AND ISCHEMIA IN THE RAT-BRAIN CORTEX
EXTRACELLULAR ION CONCENTRATIONS DURING SPREADING DEPRESSION AND ISCHEMIA IN THE RAT-BRAIN CORTEX
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DOI：
10.1111/j.1748-1716.1981.tb06920.x
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
ZEUTHEN, T
中科院分区：
文献类型：
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作者：
HANSEN, AJ;ZEUTHEN, T
在观察到明显变化的2种条件下比较大鼠脑皮质中的间质离子浓度：扩散性抑制和缺血。最初，在2种现象期间，[K +] e从3增加到apx。观察到10 mM的浓度，但其他离子浓度只有很小的变化。此后，[K +] e迅速增加（2 - 3 s）至55 mM，而[Na +] e迅速下降至60 mM，[Cl-] e下降至75 mM，[Ca 2 +] e下降至0.08 mM。两种现象中的离子事件存在差异。在扩散性抑制，最初的[K +] e增加发生在5 - 10秒，但在缺血持续1 - 2分钟。离子扰动自发恢复在SD，但在缺血，他们进一步进行，并达到5分钟后（mM）：[K +] e 75，[Na +] e 50，[Cl-] e 72和[Ca2 +] e 0.06。在扩散性抑制和缺血期间类似的离子事件链表明离子变化的共同机制，可能涉及脑细胞离子渗透性的变化。
Interstitial ion concentrations in rat brain cortex were compared during 2 conditions where pronounced changes are observed: spreading depression and ischemia. Initially, during the 2 phenomena, an increase of [K+]e from 3 to .apprx. 10 mM was observed, but only small changes in the other ion concentrations. Hereafter, [K+]e exhibited a rapid increase (2-3 s) to 55 mM, whereas [Na+]e rapidly decreased to 60 mM, [Cl-]e to 75 mM, and [Ca2+]e to 0.08 mM. The changes were accompanied by a rapid negative shift in the local electrical potential. There were differences in the ionic events during the 2 phenomena. In spreading depression, the initial [K+]e increase took place in 5-10 s, but in ischemia it lasted 1-2 min. The ionic perturbations were spontaneously reverted in SD, but in ischemia they proceeded further and reached after 5 min (mM): [K+]e 75, [Na+]e 50, [Cl-]e 72 and [Ca2+]e 0.06. The similar chain of ionic events during spreading depression and ischemia suggests a common mechanism for the ionic changes, probably involving changes of ionic permeability of brain cells.