The dependence of spinal cord development on corticospinal input and its significance in understanding and treating spastic cerebral palsy
The dependence of spinal cord development on corticospinal input and its significance in understanding and treating spastic cerebral palsy
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DOI：
10.1016/j.neubiorev.2007.04.007
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发表时间：
2007-01-01
影响因子：
8.2
通讯作者：
Clowry, Gavin J.
中科院分区：
文献类型：
--
作者：
Clowry, Gavin J.
脊髓发育的最后阶段是下行通路的到来，这带来了重组，允许成熟的运动行为在高级大脑中心的控制下出现。在典型的人类发育过程中进行的观察表明，低阈值牵张反射，包括激动剂和拮抗剂肌肉对之间的兴奋性反射是新生儿的一个特征。然而，皮质脊髓束的围产期病变可导致脊髓反射的异常发育，包括保留和加强在成年中风患者中不会出现的发育特征，即使他们也患有痉挛。本文综述了动物模型中皮质脊髓输入如何驱动节段性成熟的研究。它将他们的研究结果与人类的观察结果进行了比较，并讨论了脑瘫的治疗干预措施如何旨在纠正下行和节段输入之间的不平衡，同时考虑到下行活动可能在发育中发挥关键作用。(c)2007爱思唯尔有限公司保留所有权利。
The final phase of spinal cord development follows the arrival of descending pathways which brings about a reorganisation that allows mature motor behaviours to emerge under the control of higher brain centres. Observations made during typical human development have shown that low threshold stretch reflexes, including excitatory reflexes between agonist and antagonist muscle pairs are a feature of the newborn. However, perinatal lesions of the corticospinal tract can lead to abnormal development of spinal reflexes that includes retention and reinforcement of developmental features that do not emerge in adult stroke victims, even though they also suffer from spasticity. This review describes investigations in animal models into how corticospinal input may drive segmental maturation. It compares their findings with observations made in humans and discusses how therapeutic interventions in cerebral palsy might aim to correct imbalances between descending and segmental inputs, bearing in mind that descending activity may play the crucial role in development. (c) 2007 Elsevier Ltd. All rights reserved.