Ovulation blocking actions of urethane in the rat.
Ovulation blocking actions of urethane in the rat.
复制标题
乌拉坦对大鼠的排卵阻断作用。
作者：
C. A. Blake;C. Sawyer
麻醉剂量的乌拉坦在大鼠发情前关键期或发情前关键期给药时，对阻断自发排卵非常有效。其主要作用似乎是阻断LH-RH从大脑中释放。该药物不作用于垂体，以显著改变腺体对外源性LH-RH的反应性。如果ip给药，乌拉坦似乎也通过外周作用阻断自发排卵：排卵阻断大鼠所需的外源性LH约为戊巴比妥阻断大鼠的5倍。即使在戊巴比妥作用下，血中LH水平远高于完全排卵所需的值，ip乌拉坦也能阻断排卵。静脉注射乌拉坦在这些情况下不能阻断排卵，而且似乎缺乏外周阻断作用。两种注射模式都会引起自主控制的特征变化。但腹腔注射乌拉坦引起腹水大量积聚，且腹腔内注射后腹水明显增多。
An anesthetic dose of urethane was found to be very effective in blocking spontaneous ovulation in the rat when administered just prior to or during the proestrous critical period. Its principal action appears to be blockade of LH—RH release from the brain. The drug does not act at the pituitary to alter significantly the gland's responsiveness to exogenous LH—RH. If administered ip urethane also appears to block spontaneous ovulation by a peripheral action: approximately 5 times as much exogenous LH is needed to ovulate urethane—blocked rats as pentobarbital— bioeked rats. Even when LH levels in the blood are elevated well above values necessary for full ovulation under pentobarbital, ip urethane can block ovulation. An iv injection of urethane does not block ovulation under these conditions, and it appears to lack the peripheral blocking effect. Both modes of injection cause characteristic changes in autonomic control. However, the ip injection of urethane causes a large accumulation of ascites fluid an...