Left Atrial Volume Index Is Associated With Cardioembolic Stroke and Atrial Fibrillation Detection After Embolic Stroke of Undetermined Source
Left Atrial Volume Index Is Associated With Cardioembolic Stroke and Atrial Fibrillation Detection After Embolic Stroke of Undetermined Source
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DOI：
10.1161/strokeaha.119.025384
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发表时间：
2019-08-01
期刊：
影响因子：
8.3
通讯作者：
Song, Christopher
中科院分区：
文献类型：
--
作者：
Jordan, Kevin;Yaghi, Shadi;Song, Christopher
背景和目的-左心房扩大已被证实与缺血性卒中有关，但与栓塞性卒中机制的关系尚不清楚。我们的目的是研究左心房容积指数（LAVI）和栓塞性中风亚型和心房颤动（AF）检测心脏事件监测不明来源的栓塞性中风患者之间的关联。方法收集数据从一个前瞻性队列连续缺血性中风患者入院综合中风中心超过18个月。卒中亚型分为心源性卒中、确定机制的非心源性卒中（NCE）和未确定来源的栓塞性卒中（ESUS）。单变量和预先指定的多变量分析进行评估LAVI和中风亚型和AF检测ESUS.Results患者之间的关联-在研究期间确定的1224例连续患者，1020（82.6%）进行了经胸超声心动图和LAVI测量。心源性栓塞性卒中患者的LAVI大于NCE（41.4 mL/m2 ± 18.0 vs 28.6 mL/m2 ± 12.2; P
Background and Purpose- Left atrial enlargement has been shown to be associated with ischemic stroke, but the association with embolic stroke mechanisms remains unknown. We aim to study the associations between left atrial volume index (LAVI) and embolic stroke subtypes and atrial fibrillation (AF) detection on cardiac event monitoring in patients with embolic stroke of unknown source.Methods- Data were collected from a prospective cohort of consecutive patients with ischemic stroke admitted to a comprehensive stroke center over 18 months. Stroke subtype was classified into cardioembolic stroke, noncardioembolic stroke of determined mechanism (NCE), or embolic stroke of undetermined source (ESUS). Univariate and prespecified multivariable analyses were performed to assess associations between LAVI and stroke subtype and AF detection in patients with ESUS.Results- Of 1224 consecutive patients identified during the study period, 1020 (82.6%) underwent transthoracic echocardiography and had LAVI measurements. LAVI was greater in patients with cardioembolic stroke than NCE (41.4 mL/m(2)18.0 versus 28.6 mL/m(2)+/- 12.2; P