Genetic influence on blood pressure measured in the office, under laboratory stress and during real life.
Genetic influence on blood pressure measured in the office, under laboratory stress and during real life.
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遗传对办公室、实验室压力下和现实生活中测量的血压有影响。
DOI：
10.1038/hr.2010.218
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Snieder,Harold
中科院分区：
文献类型：
--
作者：
Wang,Xiaoling;Ding,Xiuhua;Su,Shaoyong;Harshfield,Gregory;Treiber,Frank;Snieder,Harold
确定在办公室、实验室心理应激条件下和真实的生活中测量的血压（BP）的遗传影响有多大程度的不同。在238名欧洲裔美国人和186名非洲裔美国人双胞胎中测量了办公室血压、视频游戏挑战和社会压力访谈期间的血压以及24小时动态血压。两项任务的BP值取平均值以代表压力水平。遗传模型拟合显示，任何措施都没有种族或性别差异。模型拟合结果显示，办公室血压、压力血压和24小时收缩压（SBP）的遗传度估计值分别为63%、75%和71%，舒张压（DBP）的遗传度估计值分别为59%、67%和69%。高达81%的办公室SBP和71%的办公室DBP的遗传力归因于也影响应激BP的基因。然而，只有45%的24小时收缩压和49%的24小时舒张压的遗传力归因于基因，也影响办公室血压。类似地，24小时收缩压和24小时舒张压的遗传率分别为39%和42%，这些遗传率也与影响应激血压的基因有关。在办公室、实验室压力下和真实的生活中测量的影响血压的基因之间存在大量重叠。然而，每个BP测量特定的显着遗传成分也存在。这些结果表明，部分不同的基因或基因组有助于在不同条件下的血压调节。
To determine to what extent the genetic influences on blood pressure (BP) measured in the office, under psychologically stressful conditions in the laboratory and during real life are different from each other. Office BP, BP during a video game challenge and a social stressor interview, and 24-h ambulatory BP were measured in 238 European American and 186 African American twins. BP values across the two tasks were averaged to represent stress levels. Genetic model fitting showed no ethnic or gender differences for any of the measures. The model fitting resulted in heritability estimates of 63, 75 and 71% for office, stress and 24-h systolic BP (SBP) and 59, 67 and 69% for diastolic BP (DBP), respectively. Up to 81% of the heritability of office SBP and 71% of office DBP were attributed to genes that also influenced stress BP. However, only 45% of the heritability of 24-h SBP and 49% of 24-h DBP were attributed to genes that also influence office BP. Similarly, about 39% of the heritability of 24-h SBP and 42% of 24-h DBP were attributed to genes that also influence stress BP. Substantial overlap exists between genes that influence BP measured in the office, under laboratory stress and during real life. However, significant genetic components specific to each BP measurement also exist. These findings suggest that partly different genes or sets of genes contribute to BP regulation in different conditions.