Dystrophic ossification on trachea and bronchus
Dystrophic ossification on trachea and bronchus
复制标题
气管和支气管营养不良性骨化
DOI：
10.1111/crj.12060
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Junehwa Lee
中科院分区：
文献类型：
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作者：
Min Suk Kim;Junehwa Lee
弥漫性肺骨化（DPO）是一种罕见的疾病，其定义为肺组织内广泛的异位骨形成，分为两种类型：树状和结节状。树状肺骨化是一种来源不明的罕见疾病，其中在肺实质内发现通常含有骨髓的成熟骨。结节形式的特征是牙槽内骨沉积，通常没有骨髓成分。 DPO 通常见于老年人。患者可能无症状，也可能因基础疾病而出现症状。实验室检查结果没有诊断价值，因为血清碱性磷酸酶活性、钙和磷水平通常正常。 DPO 在胸部 X 光检查中通常是不可见的，但使用适当纵隔窗口设置的 1 毫米切片的高分辨率计算机断层扫描 (HRCT) 扫描显示胸膜下部分骨密度的分支病变。通过经支气管肺活检或开放性肺活检进行组织病理学分析通常可以给出明确的诊断 (1)。在此，我们报告一例在慢性咳嗽评估过程中检测到的特发性 DPO 病例。
Diffuse pulmonary ossification (DPO) is an uncommon condition defined by widespread heterotopic bone formation within the pulmonary tissue and divided into two types: dendriform and nodular form. Dendriform pulmonary ossification is a rare condition of unknown origin wherein mature bone, usually containing marrow, is found within the pulmonary parenchyma. The nodular form is characterized by intra-alveolar bone deposits usually without marrow elements. DPO is usually found in the elderly. Patients can be asymptomatic or have symptoms due to underlying diseases. Laboratory findings have no diagnostic value because serum alkaline phophatase activity, calcium and phosphorus levels are usually normal. DPO is usually invisible on chest X-ray, but highresolution computed tomography (HRCT) scan using 1-mm slices of appropriate mediastinal window settings shows branching lesions of bone density in the subpleural parts. Histopathologic analysis via transbronchial lung biopsy or open lung biopsy usually gives the definitive diagnosis (1). Here we report an idiopathic case of DPO detected during evaluation of chronic cough.