Expression of glial cell line-derived neurotrophic factor family members and their receptors in pancreatic cancers
Expression of glial cell line-derived neurotrophic factor family members and their receptors in pancreatic cancers
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DOI：
10.1016/j.surg.2005.07.007
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发表时间：
2005-10-01
期刊：
影响因子：
3.8
通讯作者：
Manabe, T
中科院分区：
文献类型：
--
作者：
Ito, Y;Okada, Y;Manabe, T
背景胶质细胞源性神经营养因子（glial cell line-derived neurotrophic factor，GDNF）是神经营养多肽家族的一员，在中枢和外周神经系统中促进各种神经细胞的存活和拯救。我们先前报道GDNF促进胰腺癌细胞系中肿瘤细胞的侵袭。本研究的目的是调查GDNF家族的表达和相关受体在实际癌组织中的状态，并评估与临床病理行为的相关性。对51例手术切除的胰腺癌组织进行GDNF、neurturin、persephin、artemin、GDNF家族受体α 1和α 2以及RET的免疫组化检测。胰内神经GDNF和artermin均呈强阳性表达。在胰腺癌组织中。RET的表达强于正常导管细胞，并与切除后的生存率（P = 0.026）和淋巴管浸润（P = 0.014）显著相关。胰腺内神经侵犯与GDAT表达显著相关（P = 0.047）。结论RET在胰腺癌组织中的表达可能是一个有用的预后指标，GDNF可能在神经侵袭中起重要作用。
Background. The glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic Polypeptide family, which promotes survival and rescue of various neural cells in the central and peripheral nerve systems. We previously reported that GDNF promotes tumor cell invasion in pancreatic cancer cell lines. The purpose of this study was to investigate GDNF family expression and the status of related receptors in actual cancer tissues, and assess correlations with clinicopathologic behavior.Methods. Immunohistochemical assessment of GDNF, neurturin, persephin, artemin, GDNF family receptor alpha-1 and alpha-2, and RET was performed for 51 cases of surgically resected pancreatic cancer.Results. In all intrapancreatic nerves, GDNF and artermin were expressed strongly. In pancreatic cancer tissues. The expression of RET was stronger than that seen in normal ductal cells and was significantly related to the survival rate after resection (P = .026) and lymphatic invasion (P = .014). Intrapancreatic neural invasion was significantly related to the expression of GDAT (P = .047).Conclusions. We conclude that the expression of RET in pancreatic cancer tissues may be a useful prognostic marker and GDNF may play an important role in neural invasion.