Effects of Schistosoma mansoni worms and eggs on circulating cholesterol and liver lipids in mice
Effects of Schistosoma mansoni worms and eggs on circulating cholesterol and liver lipids in mice
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DOI：
10.1016/j.atherosclerosis.2009.04.037
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发表时间：
2009-11-01
期刊：
影响因子：
5.3
通讯作者：
Doenhoff, Michael J.
中科院分区：
文献类型：
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作者：
Stanley, Ronald G.;Jackson, Christopher L.;Doenhoff, Michael J.
此前已有研究表明，曼氏血吸虫成虫寄生在哺乳动物宿主的血流中，实验性感染可显着减少载脂蛋白 E 基因敲除 (apoE(-/-)) 小鼠的动脉粥样硬化形成。这些效应与 apoE(-/-) 和随机饲养的实验小鼠血清总胆固醇水平降低以及 HDL 与 LDL 胆固醇比例有益增加同时发生。为了更好地了解寄生虫感染如何引起这些影响，我们在这里研究了成虫及其卵对宿主脂质的影响。我们的结果表明，降低血清胆固醇的作用是由曼氏链霉菌卵释放的因子介导的，而成虫的存在似乎几乎没有影响。还观察到，随机饲养的小鼠和喂食高脂肪饮食的 apoE(-/-) 小鼠的未感染肝脏中存在高水平的脂质，特别是三酰甘油和胆固醇酯，但在血吸虫感染的小鼠的肝脏中不存在。 (C) 2009 Elsevier Ireland Ltd. 保留所有权利。
It has previously been shown that experimental infections of the parasitic trematode Schistosoma mansoni, the adult worms of which reside in the blood stream of the mammalian host, significantly reduced atherogenesis in apolipoprotein E gene knockout (apoE(-/-)) mice. These effects occurred in tandem with a lowering of serum total cholesterol levels in both apoE(-/-) and random-bred laboratory mice and a beneficial increase in the proportion of HDL to LDL cholesterol. To better understand how the parasitic infections induce these effects we have here investigated the involvement of adult worms and their eggs on lipids in the host. Our results indicate that the serum cholesterol-lowering effect is mediated by factors released from S. mansoni eggs, while the presence of adult worms seemed to have had little or no effect. It was also observed that high levels of lipids, particularly triacylglycerols and cholesteryl esters, present in the uninfected livers of both random-bred and apoE(-/-) mice fed a high-fat diet were not present in livers of the schistosome-infected mice. (C) 2009 Elsevier Ireland Ltd. All rights reserved.