Impact of portal venous pressure on regeneration and graft damage after living-donor liver transplantation
Impact of portal venous pressure on regeneration and graft damage after living-donor liver transplantation
复制标题
DOI：
10.1002/lt.20317
复制
发表时间：
2005-01-01
影响因子：
4.6
通讯作者：
Uemoto, S
中科院分区：
文献类型：
--
作者：
Yagi, S;Iida, T;Uemoto, S
一些报告声称，活体肝移植（LDLT）后门静脉高压症对移植物功能有不良影响，但很少有人评估门静脉压力（PVP）对移植物再生的影响。我们根据LDLT后前3天的平均PVP将32例成人LDLT受者分为PVP大于或等于20 mm Hg的组（H组; n = 17）和PVP < 20 mm Hg的组（L组; n = 15）。H组的结局比L组差（1年时58.8% vs. 92.9%）。H组在前2周的外周肝细胞生长因子（HGF）峰值较高（L：1，730 pg/mL，H：3，696 pg/mL; P <0.01），而L组在第1周的门静脉血管内皮生长因子（VEGF）峰值较高（L：433 pg/mL，H：92 pg/mL; P <0.05）。H组的移植物体积（GV）/标准肝脏体积（SLV）较高（L / H，2、3、4周和3个月时分别为1.02 /1.24、.916/1.16、.98/ 1.27和.94 / 1.29; P
Several reports claim that portal hypertension after living-donor liver transplantation (LDLT) adversely affects graft function, but few have assessed the impact of portal venous pressure (PVP) on graft regeneration. We divided 32 adult LDLT recipients based on mean PVP during the 1st 3 days after LDLT into a group with a PVP greater than or equal to 20 mm of Hg (H Group; n = 17), and a group with a PVP < 20 mm of Hg (L Group; n = 15). Outcome in the H Group was poorer than in the L Group (58.8 vs. 92.9% at 1 year). Peak peripheral hepatocyte growth factor (HGF) during the 1st 2 weeks was higher in the H Group (L: 1,730 pg/mL, H: 3,696 pg/mL; P < .01), whereas peak portal vascular endothelial growth factor (VEGF) level during the 1 st week was higher in the L Group (L: 433 pg/mL, H: 92 pg/mL; P < .05). Graft volume (GV) / standard liver volume (SLV) was higher in the H Group (L / H, at 2, 3, and 4 weeks, and at 3 months: 1.02 / 1.24,.916 / 1.16,.98 / 1.27, and .94 / 1.29, respectively; P