Lack of support for the inability to taste phenylthiocarbamide as an endophenotypic marker in patients with schizophrenia and their first-degree relatives
Lack of support for the inability to taste phenylthiocarbamide as an endophenotypic marker in patients with schizophrenia and their first-degree relatives
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DOI：
10.1016/j.schres.2007.07.007
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发表时间：
2007-09-01
影响因子：
4.5
通讯作者：
Walker, Elaine F.
中科院分区：
文献类型：
--
作者：
Compton, Michael T.;Chien, Victoria H.;Walker, Elaine F.
目的：这项研究试图复制最近的研究结果，即患者和亲属都显着更有可能是苯硫脲（PTC）nontasters比健康对照组，在患者组，nontasters有更严重的阳性和/或阴性症状比品尝。PTC品尝状态和嗅觉识别scores之间的关联也examined.Method：PTC感知和嗅觉识别进行了评估，在48例精神分裂症或情感性精神障碍，28个一级亲属，和32名健康志愿者。结果在以下情况下未发生变化：一项敏感性分析，将“可能”品尝PTC的参与者重新分类，排除白人参与者，或将患者样本限制为仅精神分裂症患者。在患者中，味觉者和味觉不者在阳性、阴性或一般精神病理学症状方面没有差异。在合并后的样本和三个组分别，PTC品尝状态和嗅觉鉴定scores.Conclusions之间没有关联：这项研究，专门进行作为一种尝试，以复制以前报道的结果，未能提供支持PTC知觉作为精神分裂症的内表型标记。进一步的研究是必要的。(c)2007 Elsevier B.V保留所有权利。
Objective: This study sought to replicate recent findings that both patients and relatives are significantly more likely to be phenylthiocarbamide (PTC) nontasters than healthy controls, and that within the patient group, nontasters have more severe positive and/or negative symptoms than tasters. Associations between PTC-tasting status and olfactory identification scores also were examined.Method: PTC perception and olfactory identification were assessed in 48 patients with schizophrenia or schizoaffective disorder, 28 first-degree relatives, and 32 healthy volunteers.Results: The three groups did not differ in PTC taste sensitivity. Findings did not change after: a sensitivity analysis that recategorized participants who "possibly" tasted PTC, excluding Caucasian participants, or restricting the sample of patients to only those with schizophrenia. Among the patients, tasters and nontasters did not differ with regard to positive, negative, or general psychopathology symptoms. In the combined sample and the three groups separately, there were no associations between PTC-tasting status and olfactory identification scores.Conclusions: This study, conducted specifically as an attempt to replicate previously reported findings, failed to provide support for PTC perception as an endophenotypic marker for schizophrenia. Further research is warranted. (c) 2007 Elsevier B.V All rights reserved.