Lesion size changes in osteonecrosis of the femoral head: a long-term prospective study using MRI.
Lesion size changes in osteonecrosis of the femoral head: a long-term prospective study using MRI.
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股骨头坏死的病灶大小变化：使用 MRI 的长期前瞻性研究。
DOI：
10.1007/s00264-009-0829-7
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发表时间：
2010-08
影响因子：
2.7
通讯作者：
Liu, Zhao-hui
中科院分区：
文献类型：
--
作者：
Zhao, Feng-chao;Li, Zi-rong;Zhang, Nian-fei;Wang, Bai-liang;Sun, Wei;Cheng, Li-ming;Liu, Zhao-hui
股骨头坏死（Osteonecrosis of the femoral head，ONFH）是一种难治性疾病。磁共振成像（MRI）评估的病变大小是否会随着时间的推移而改变，而无需任何手术治疗，这是有争议的。本研究应用MRI观察严重急性呼吸综合征（SARS）患者激素治疗后股骨头坏死病灶大小的变化。本研究包括51例（84髋）SARS早期股骨头坏死患者，均未接受任何手术治疗，经MRI诊断。所有患者均接受MRI随访。在每次随访时，根据MRI上的病变体积对每位患者进行评价，以进行进一步比较。首次MRI扫描时，平均病变体积为10.12 ± 8.05 cm 3（范围：0.39-41.62 cm 3）。中期随访（2.5年）时，平均病变体积为7.82 ± 7.59 cm 3（范围：0.11-39.65 cm 3）。在最终随访（5年）时，在6个髋关节中观察到病变完全消退，平均病变体积为5.67 ± 6.58 cm 3（范围：0.00-31.47 cm 3）。总的来说，80个髋关节的病变体积减少了15%以上，只有4个病变体积相对较大的髋关节没有明显减少。在MRI上观察到的ONFH病变大小的缩小是一个缓慢的、不连续的和时间依赖性的过程。
Osteonecrosis of the femoral head (ONFH) is one of the intractable diseases. It is controversial whether the lesion size assessed by magnetic resonance imaging (MRI) can change over time without any operative treatment. In this study, we used MRI to observe the lesion size changes of ONFH induced by corticosteroid administration in severe acute respiratory syndrome (SARS) patients. The study included 51 SARS patients (84 hips) with early-stage ONFH who did not receive any operative treatment and were diagnosed by MRI. All of the patients underwent MRI follow-ups. Each patient was evaluated on the basis of the lesion volume on MRI at every follow-up for further comparisons. At the first MRI scan, the mean lesion volume was 10.12 ± 8.05 cm3 (range: 0.39–41.62 cm3). At the mid-term follow-up (2.5 years), the mean lesion volume was 7.82 ± 7.59 cm3 (range: 0.11–39.65 cm3). At the final follow-up (five years), complete regression of the lesion was observed in six hips, and the mean lesion volume was 5.67 ± 6.58 cm3 (range: 0.00–31.47 cm3). Overall, the lesion volume was reduced by >15% in 80 hips, and only four hips with relatively larger lesion volumes showed no apparent reductions. The reduction in lesion size of ONFH observed on MRI is a slow, discontinuous and time-dependent process.
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影响因子：
4.5
作者：
Chan MH;Chan PK;Griffith JF;Chan IH;Lit LC;Wong CK;Antonio GE;Liu EY;Hui DS;Suen MW;Ahuja AT;Sung JJ;Lam CW
通讯作者：
Lam CW
DOI：
10.1097/01.blo.0000150275.98701.4e
发表时间：
2004-12-01
影响因子：
4.2
作者：
Hungerford, DS;Jones, LC
通讯作者：
Jones, LC
影响因子：
5
作者：
Ito, Hiroshi;Matsuno, Takeo;Minami, Akio
通讯作者：
Minami, Akio
DOI：
10.1302/0301-620x.81b4.9393
发表时间：
1999-07-01
影响因子：
--
作者：
Sugano, N;Kubo, T;Ninomiya, S
通讯作者：
Ninomiya, S
DOI：
10.1097/01.blo.0000037441.23683.ee
发表时间：
2003-01-01
影响因子：
4.2
作者：
Kim, YM;Rhyu, KH;Kim, HJ
通讯作者：
Kim, HJ