Possible renoprotective mechanisms of SGLT2 inhibitors.
Possible renoprotective mechanisms of SGLT2 inhibitors.
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DOI：
10.3389/fmed.2023.1115413
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发表时间：
2023
影响因子：
3.9
通讯作者：
Kitada, Kento
中科院分区：
文献类型：
--
作者：
Nishiyama, Akira;Kitada, Kento
关键词：
钠葡萄糖协同转运蛋白2（SGLT 2）抑制剂治疗慢性肾脏病患者可降低肾脏风险，与血糖浓度和血压变化无关。然而，SGLT 2受体诱导的肾保护作用的确切机制尚不清楚。我们之前已经证明SGLT 2抑制剂诱导抗高血压作用，交感神经活动减少，这与短暂性尿钠排泄相关。此外，SGLT 2抑制剂治疗通过在肾小管中产生血管内皮生长因子-a改善肾缺血。其他研究表明，酮体产生、肾小球血流动力学变化和肾内代谢变化以及肾小管间质葡萄糖水平降低导致的氧化应激降低也可能参与SGLT 2抑制剂的肾保护作用。在这篇综述中，我们总结了SGLT 2受体诱导的肾脏保护作用的机制，包括我们最近关于“夏眠样反应”的假说，这是一种对饥饿的生物防御反应。
Treatment with a sodium glucose cotransporter 2 (SGLT2) inhibitor in patients with chronic kidney disease reduces the renal risk independent of changes in blood glucose concentrations and blood pressure. However, the precise mechanism responsible for this SGLT2 inhibitor-induced renoprotective effect is unclear. We have previously shown that SGLT2 inhibitors induce antihypertensive effects with decreased sympathetic nerve activity, which is associated with transient natriuresis. Furthermore, treatment with an SGLT2 inhibitor improves renal ischemia by producing vascular endothelial growth factor-a in the renal tubules. Other studies have suggested that ketone body production, changes in glomerular hemodynamics, and intrarenal metabolic changes and a reduction in oxidative stress due to decreased tubulointerstitial glucose levels may also be involved in the renoprotective effects of SGLT2 inhibitors. In this review, we summarize the mechanism responsible for the SGLT2 inhibitor-induced renoprotective effects, including our recent hypothesis regarding an “aestivation-like response,” which is a biological defense response to starvation.
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影响因子：
9.3
作者：
Shimizu W;Kubota Y;Hoshika Y;Mozawa K;Tara S;Tokita Y;Yodogawa K;Iwasaki YK;Yamamoto T;Takano H;Tsukada Y;Asai K;Miyamoto M;Miyauchi Y;Kodani E;Ishikawa M;Maruyama M;Ogano M;Tanabe J;EMBODY trial investigators
通讯作者：
EMBODY trial investigators
影响因子：
3.7
作者：
Kapoor S;Rodriguez D;Riwanto M;Edenhofer I;Segerer S;Mitchell K;Wüthrich RP
通讯作者：
Wüthrich RP
影响因子：
5.4
作者：
Takeshige, Yui;Fujisawa, Yoshihide;Nishiyama, Akira
通讯作者：
Nishiyama, Akira
影响因子：
158.5
作者：
Perkovic, V.;Jardine, M. J.;Bentley-Lewis, Rhonda
通讯作者：
Bentley-Lewis, Rhonda
影响因子：
8.2
作者：
Ghezzi C;Loo DDF;Wright EM
通讯作者：
Wright EM