Oxidative and endoplasmic reticulum stress in respiratory disease.

Oxidative and endoplasmic reticulum stress in respiratory disease.
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DOI:
10.1002/cti2.1019
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发表时间:
2018
影响因子:
5.8
通讯作者:
McGuckin MA
McGuckin MA
中科院分区:
医学3区
文献类型:
--
作者:
Chen AC;Burr L;McGuckin MA

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氧化应激和内质网(ER)应激是相关的状态,其可以作为正常生理学的一部分发生在细胞中,但经常发生在涉及炎症的疾病中。在这篇文章中,我们回顾了最近的研究结果有关的作用,氧化和ER应激的病理生理学的急性和慢性非恶性疾病的肺,包括感染,囊性纤维化,特发性肺纤维化和哮喘。我们还探索了靶向氧化和ER应激途径的药物缓解疾病的潜力。
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