Immunological capabilities of skeletal muscle cells
Immunological capabilities of skeletal muscle cells
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DOI：
10.1046/j.1365-201x.2001.00823.x
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发表时间：
2001-03-01
期刊：
影响因子：
--
通讯作者：
Nagaraju, K
中科院分区：
文献类型：
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作者：
Nagaraju, K
肌肉是多种肌肉疾病中免疫损伤的靶点。因此，了解肌肉细胞自身的免疫能力是很重要的。虽然讨论免疫系统对其他细胞、组织或器官的影响是常规的，但系统的边界不能被清晰地划分，并且在越来越多的方式中，非免疫组织的免疫能力被认为是决定免疫炎症过程的过程。肌细胞具有在炎症条件下表达和响应多种免疫相关表面分子、细胞因子和趋化因子的固有能力。肌肉细胞的处理和目前的免疫细胞的抗原的能力是有争议的，因此，这篇评论的目的是在体外和体内骨骼肌细胞的免疫能力进行检查。
Muscle is the target of immunological injury in several muscle diseases. It is important therefore to understand the immunological capabilities of muscle cells themselves. Although it is conventional to discuss the effects of the immune system on other cells, tissues or organs, the system's boundaries cannot be sharply drawn, and in an increasing number of ways, the immunological capabilities of non-immune tissues are recognized as determining the course of immune-inflammatory processes. Muscle cells have an inherent ability to express and respond to a variety of immunologically relevant surface molecules, cytokines, and chemokines under inflammatory conditions. The ability of muscle cells to process and present antigens to the immune cells is currently debated; thus, this review is aimed at examining the immunological capabilities of skeletal muscle cells in vitro and in vivo.