mir-146a and mir-155 expression levels in acute graft-Versus-host Disease incidence
mir-146a and mir-155 expression levels in acute graft-Versus-host Disease incidence
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mir-146a 和 mir-155 在急性移植物抗宿主病发病率中的表达水平
DOI：
10.3389/fimmu.2016.00056
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发表时间：
2016-03-08
影响因子：
7.3
通讯作者：
Dickinson, Anne Mary
中科院分区：
文献类型：
--
作者：
Atarod, Sadaf;Ahmed, Mohammed Mahid;Dickinson, Anne Mary
同种异体造血干细胞移植是治疗多种恶性血液病的有效方法。然而，急性移植物抗宿主病（aGVHD）仍然是导致死亡的主要并发症。MicroRNAs （miRNAs）在炎症中发挥着重要作用，具有作为预后和诊断生物标志物的潜力。本研究探讨了两种免疫特异性mirna （miR-146a和miR-155）作为疾病发病前异基因造血干细胞患者外周血aGVHD发病率的生物标志物的作用。研究表明，miR-146a及其与miR-155在第28天的统计学相互作用可预测aGVHD的发病率。有趣的是，miR-146a和miR-155的表达水平与转录因子SPI1 (PU.1gene) mRNA的表达呈负相关。
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGVHD) is still the major complication causing mortality. MicroRNAs (miRNAs) play a significant role in inflammation and have potential as prognostic and diagnostic biomarkers. This study investigated the role of two immune-specific miRNAs (miR-146a and miR-155) as biomarkers for aGVHD incidence in the peripheral blood of allo-HSCT patients prior to disease onset. The study showed that miR-146a and its statistical interaction with miR-155 at day +28 were predictive of aGVHD incidence. Interestingly, the expression levels of miR-146a and miR-155 negatively correlated with the transcription factor, SPI1 (PU.1gene) mRNA expression.