Fraction of head and neck cancer attributable to tobacco and alcohol in cities of three Brazilian regions
Fraction of head and neck cancer attributable to tobacco and alcohol in cities of three Brazilian regions
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DOI：
10.1590/1980-549720180005
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发表时间：
2018-01-01
影响因子：
--
通讯作者：
Wünsch Filho, Victor
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文献类型：
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作者：
Kfouri, Suely Aparecida;Eluf Neto, José;Wünsch Filho, Victor
目的：估计巴西中西部、东南部和南部地区城市中由烟草和酒精引起的头颈癌 (HNC) 的比例。方法：病例对照研究，包括 1,594 例 HNC 病例和 1,292 例医院对照。 HNC 与烟草和酒精的关联是通过非条件逻辑回归，根据比值比和各自的 95% 置信区间来估计的，并根据年龄、性别、受教育程度、水果和蔬菜的消费、饮酒（以检查烟草影响）和吸烟（以检查酒精影响）进行调整。通过归因分数（AF）计算来估算可归因于烟草和酒精的 HNC 比例。对戈亚尼亚（中西部）、里约热内卢和圣保罗（东南部）以及佩洛塔斯和阿雷格里港（南部）进行了单独估计。 结果：戈亚尼亚的 HNC 比例（AF = 90%）略高于东南部城市（AF = 87%）和南部城市（AF = 86%）。东南部城市 (AF = 78%) 和南部城市 (AF = 77%) 与戈亚尼亚城市 (AF = 62%) 的结果相似，但归因于酒精饮料消费的 HNC 分数则更高。 结论：归因于吸烟的 HNC 分数比饮酒更具有表现力。尽管它们之间存在离散的区别，但在这三个巴西地区的城市中观察到的 HNC 中吸烟和饮酒的 AF 与拉丁美洲研究中获得的结果相似，但高于世界其他地区。
OBJECTIVES: To estimate the fraction of head and neck cancer (HNC) attributable to tobacco and alcohol in cities in the Midwest, Southeast and South regions of Brazil.METHODS: Case-control study including 1,594 cases of HNC and 1,292 hospital controls. The association of HNC with tobacco and alcohol was estimated by the odds ratio and respective 95% confidence intervals through non-conditional logistic regression, adjusted for age, sex, schooling, consumption of fruits and vegetables, alcohol drinking (to examine the tobacco effect), and tobacco smoking (to examine the alcohol effect). The proportions of HNC attributable to tobacco and alcohol were estimated through the attributable fraction (AF) calculation. Separate estimates were made for Goiania (Midwest), Rio de Janeiro and Sao Paulo (Southeast) and Pelotas and Porto Alegre (South).RESULTS: The HNC fraction attributable to smoking was slightly higher in Goiania (AF = 90%) than in cities in the Southeast (AF = 87%) and South (AF = 86%). The HNC fraction attributable to the consumption of alcoholic beverages presented similar and higher results in the cities of Southeast (AF = 78%) and South (AF = 77%) than in Goiania (AF = 62%).CONCLUSION: The HNC fractions attributable to smoking were more expressive than for alcohol consumption. Although with discrete distinctions between them, the AFs to tobacco smoking and alcohol consumption in HNC observed in the cities of these three Brazilian regions were similar to those obtained in Latin America studies, but they were higher than in other parts in the world.