Annual Report to the Nation on the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State.
Annual Report to the Nation on the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State.
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DOI：
10.1093/jnci/djv048
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Penberthy L
中科院分区：
文献类型：
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作者：
Kohler BA;Sherman RL;Howlader N;Jemal A;Ryerson AB;Henry KA;Boscoe FP;Cronin KA;Lake A;Noone AM;Henley SJ;Eheman CR;Anderson RN;Penberthy L
美国癌症协会（ACS），疾病控制和预防中心（CDC），国家癌症研究所（NCI）和北美中央癌症登记协会（NAACCR）每年合作产生最新的国家癌症统计数据。这份年度报告包括使用新的国家级数据按亚型分列的乳腺癌发病率。计算了基于人群的癌症趋势和分子亚型的乳腺癌发病率。使用激素受体（HR）和人生长因子-neu受体（HER 2）表达的肿瘤生物标志物对乳腺癌亚型进行分类。从2007年到2011年，男性癌症发病率每年下降1.8%。1998年至2011年，妇女的比率保持稳定。在这些趋势中，存在种族/民族差异，一些研究中心的发病率有所上升。在儿童中，发病率在过去十年中继续以每年0.8%的速度增长，而与成人一样，死亡率下降。自1990年代初以来，男女总死亡率一直在下降，自1970年代以来，儿童总死亡率一直在下降。HR+/HER 2-乳腺癌是预后最好的亚型，在所有人种/种族中最常见，在非西班牙裔白色女性、局部分期病例和低贫困地区中发生率最高（分别为每10万名非西班牙裔白色女性92.7、63.51和98.69例）。HR+/HER 2-乳腺癌发病率与乳腺X线摄影的使用密切相关，尤其是非西班牙裔白色女性（Pearson 0.57，双侧P < .001）。三阴性乳腺癌是预后最差的亚型，在非西班牙裔黑人妇女中发病率最高（每10万非西班牙裔黑人妇女中有27.2例），这反映在东南部各州的高发病率上。美国在减少癌症负担方面继续取得进展。乳腺癌亚型有独特的种族/民族特异性发病模式;可能是由于生物和社会风险因素，包括乳房X线检查使用的变化。乳腺癌亚型分析证实，癌症登记处有能力根据不断发展的医学知识调整国家收集标准，以产生临床相关数据。
The American Cancer Society (ACS), Centers for Disease Control and Prevention (CDC), National Cancer Institute (NCI), and North American Association of Central Cancer Registries (NAACCR) collaborate annually to produce updated, national cancer statistics. This Annual Report includes a focus on breast cancer incidence by subtype using new, national-level data. Population-based cancer trends and breast cancer incidence by molecular subtype were calculated. Breast cancer subtypes were classified using tumor biomarkers for hormone receptor (HR) and human growth factor-neu receptor (HER2) expression. Overall cancer incidence decreased for men by 1.8% annually from 2007 to 2011. Rates for women were stable from 1998 to 2011. Within these trends there was racial/ethnic variation, and some sites have increasing rates. Among children, incidence rates continued to increase by 0.8% per year over the past decade while, like adults, mortality declined. Overall mortality has been declining for both men and women since the early 1990’s and for children since the 1970’s. HR+/HER2- breast cancers, the subtype with the best prognosis, were the most common for all races/ethnicities with highest rates among non-Hispanic white women, local stage cases, and low poverty areas (92.7, 63.51, and 98.69 per 100000 non-Hispanic white women, respectively). HR+/HER2- breast cancer incidence rates were strongly, positively correlated with mammography use, particularly for non-Hispanic white women (Pearson 0.57, two-sided P < .001). Triple-negative breast cancers, the subtype with the worst prognosis, were highest among non-Hispanic black women (27.2 per 100000 non-Hispanic black women), which is reflected in high rates in southeastern states. Progress continues in reducing the burden of cancer in the United States. There are unique racial/ethnic-specific incidence patterns for breast cancer subtypes; likely because of both biologic and social risk factors, including variation in mammography use. Breast cancer subtype analysis confirms the capacity of cancer registries to adjust national collection standards to produce clinically relevant data based on evolving medical knowledge.