The effects of deprenyl on methamphetamine-induced dopamine depletions.
The effects of deprenyl on methamphetamine-induced dopamine depletions.
复制标题
丙炔苯丙胺对甲基苯丙胺引起的多巴胺消耗的影响。
DOI：
10.1007/bf01245358
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Wagner,GC
中科院分区：
文献类型：
--
作者：
Johnson,SK;Medina,D;Wagner,GC
研究了去丙烯醇对甲基苯丙胺所致小鼠多巴胺消耗的影响。每隔两小时注射四次12.5 mg/kg的甲基安非他命，造成纹状体多巴胺大量（72-82%）和持久的消耗。用25或40 mg/ kg去戊烯醇预处理并没有显著改变这种消耗的幅度。这些结果表明，与MPTP后观察到的不同，去丙烯醇预处理在帕金森病的甲基苯丙胺模型中没有对多巴胺能细胞提供保护。
The effects of deprenyl on methamphetamine-induced dopamine depletions were studied in mice. Four SC injections of 12.5 mg/kg of methamphetamine at two-hour intervals caused substantial (72–82%) and longlasting depletions of striatal dopamine. Pretreatment with either 25 or 40 mg/ kg of deprenyl did not significantly alter the magnitude of this depletion. These results indicate that, unlike what is observed following MPTP, there is no protection afforded dopaminergic cells by deprenyl pretreatment in the methamphetamine model of parkinsonism.