Resistant starch lowers fecal concentrations of ammonia and phenols in humans
Resistant starch lowers fecal concentrations of ammonia and phenols in humans
复制标题
DOI：
10.1093/ajcn/63.5.766
复制
发表时间：
1996-05-01
影响因子：
7.1
通讯作者：
ODea, K
中科院分区：
文献类型：
--
作者：
Birkett, A;Muir, J;ODea, K
我们研究了抗性淀粉（RS）对结肠蛋白质代谢标志物的影响。11名受试者参加了一项随机交叉研究，在研究中，他们食用高RS（39 +/- 3 g/d，（x）在条形图+/- SEM上）或低RS（5 +/- 0.4 g/d）饮食3周。所有其他常量营养素保持不变。在高RS饮食期间，粪便氮的日排泄量从1.84 +/- 0.15增加到2.86 +/- 0.42 g/d（P < 0.01），粪便酚的排泄量从9.2 +/- 1.4下降到5.3 +/- 0.8 mg/d（P < 0.01）。粪便中氨的浓度从397 +/- 33降至278 +/- 49 μ g/g（P < 0.01），酚类从69 +/- 8降至39 +/- 10 μ g/g（P < 0.001）。在高RS期间，尿氨、尿素、酚类和总氮的日排出量没有显著变化，但pH从6.4 +/-0.1降至6.2 +/-0.1（P < 0.05）。这些结果表明RS显著减弱了人体结肠中蛋白质发酵的潜在有害副产物的积累。
We investigated the effect of resistant starch (RS) on markers of colonic protein metabolism. Eleven subjects participated in a randomized crossover study in which they consumed either high-RS (39 +/- 3 g/d, (x) over bar +/- SEM) or low-RS (5 +/- 0.4 g/d) diets for 3 wk. All other macronutrients were kept constant. During the high-RS diet daily excretion of fecal nitrogen increased from 1.84 +/- 0.15 to 2.86 +/- 0.42 g/d (P < 0.01) and excretion of fecal phenols fell from 9.2 +/- 1.4 to 5.3 +/- 0.8 mg/d (P < 0.01). Fecal concentrations of ammonia decreased from 397 +/- 33 to 278 +/- 49 mu g/g (P < 0.01) and phenols decreased from 69 +/- 8 to 39 +/- 10 mu g/g (P < 0.001). Daily output of urinary ammonia, urea, phenols, and total nitrogen did not change significantly, but pH decreased from 6.4 +/- 0.1 to 6.2 +/- 0.1 (P < 0.05) during the high-RS period, These results suggest that RS significantly attenuates the accumulation of potentially harmful byproducts of protein fermentation in the human colon.