Sexually transmitted and reproductive tract infections in symptomatic clients of pharmacies in Lima, Peru
Sexually transmitted and reproductive tract infections in symptomatic clients of pharmacies in Lima, Peru
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DOI：
10.1136/sti.2006.022657
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发表时间：
2007-04-01
影响因子：
3.6
通讯作者：
Holmes, K. K.
中科院分区：
文献类型：
--
作者：
Garcia, P. J.;Carcamo, C. P.;Holmes, K. K.
目的：探讨性传播和生殖道感染在寻求药物治疗的男性和女性中的流行情况和预测因素。方法：在秘鲁利马的12家中心药店和52家较小的药店登记有尿液或排尿困难和阴道分泌物的男性和女性。所有参与者都回答了一份调查问卷。男性提供尿液，用于淋球菌和沙眼衣原体的聚合酶链式反应(PCR)测试，以及白细胞酯酶测试。结果：在10 6名有症状的男性中，淋球菌和沙眼衣原体的检出率为34%，与单纯排尿困难(优势比(OR)4.3，p=0.003)、尿白细胞酯酶试验阳性(OR7.4，p=0.009)、文化程度低(OR5.5，p=0.0 3)、症状持续5天(OR2.5，p=0.0 3)相比，与排尿困难(OR=4.3，p=0.0 3)有关。在121名有症状的妇女中，39%患有细菌性阴道病或阴道T菌病，7.7%患有念珠菌病。12.4%的妇女检出淋球菌和沙眼衣原体。总体而言，48.8%的人有一种或多种此类感染。与阴道感染无关，只有持续5天的阴道分泌物症状与淋球菌和沙眼衣原体相关(OR 4.0，p=0.02)。男性和女性到药店寻求咨询的主要原因是对药房工作人员的信任。结论：到药店就诊的男性和女性中，有尿路和阴道症状的男性和女性的尿路和阴道感染率与其他临床环境中的相似。药房可以为发展中国家的性传播感染的护理和预防作出贡献。
Objective: To determine prevalences and predictors of sexually transmitted and reproductive tract infections among men and women seeking care at pharmacies.Methods: Men and women with urethral discharge or dysuria and vaginal discharge were enrolled at 12 central and 52 smaller pharmacies in Lima, Peru. All participants answered a questionnaire. Men provided urine for polymerase chain reaction ( PCR) testing for Neisseria gonorrhoeae and Chlamydia trachomatis, and for leucocyte esterase testing. Women provided self-obtained vaginal swabs for PCR testing for N gonorrhoeae and C trachomatis, Trichomonas vaginalis culture and bacterial vaginosis and Candida.Results: Among 106 symptomatic men, N gonorrhoeae and C trachomatis were detected in 34% and were associated with urethral discharge compared with dysuria only ( odds ratio ( OR) 4.3, p = 0.003), positive urine leucocyte esterase testing ( OR 7.4, p = 0.009), less education ( OR 5.5, p = 0.03), and with symptoms for < 5 days ( OR 2.5, p = 0.03). Among 121 symptomatic women, 39% had bacterial vaginosis or T vaginalis, and 7.7% had candidiasis. N gonorrhoeae and C trachomatis were detected in 12.4% of the women. Overall, 48.8% had one or more of these infections. No factors were associated with vaginal infection, and only symptoms of vaginal discharge for < 5 days were associated with N gonorrhoeae and C trachomatis ( OR 4.0, p = 0.02). The main reason reported for seeking advice at pharmacies by both men and women was trust in pharmacy workers.Conclusions: Among men and women presenting to pharmacies with urethral and vaginal symptoms, rates of urethral and vaginal infections were comparable to those found in other clinical settings. Pharmacies can contribute to the care and prevention of sexually transmitted infection in developing countries.