MOF-Derived Double-Layer Hollow Nanoparticles with Oxygen Generation Ability for Multimodal Imaging-Guided Sonodynamic Therapy
MOF-Derived Double-Layer Hollow Nanoparticles with Oxygen Generation Ability for Multimodal Imaging-Guided Sonodynamic Therapy
复制标题
MOF 衍生的具有产氧能力的双层空心纳米粒子，用于多模态成像引导声动力治疗
DOI：
10.1002/anie.202004894
复制
发表时间：
2020-06-03
影响因子：
16.6
通讯作者：
Liu, Huiyu
中科院分区：
文献类型：
--
作者：
Pan, Xueting;Wang, Weiwei;Liu, Huiyu
声敏剂系统的高活性氧（ROS）产生能力和简单的结构在针对缺氧肿瘤的声动力疗法中仍然具有挑战性。在这项工作中，我们合理地制备了MOF衍生的双层空心硅酸锰纳米颗粒（DHMS），在超声照射下具有高效的ROS产量，用于多模态成像引导的声动力治疗（SDT）。 DHMS 中 Mn 的存在提高了 ROS 生成效率，因为它可以被空穴氧化，从而改善电子空穴分离。此外，DHMS可以在肿瘤微环境中产生氧气，有助于克服实体瘤的缺氧，从而提高治疗效率。体内实验证明，在超声和磁共振成像引导下，DHMS 介导的 SDT 能够有效抑制肿瘤。这项工作提出了一种具有声敏和产氧能力的 MOF 衍生纳米颗粒，为 SDT 中肿瘤缺氧提供了一种有前景的策略。
The high reactive oxygen species (ROS) generation ability and simple construction of sonosensitizer systems remain challenging in sonodynamic therapy against the hypoxic tumor. In this work, we rationally prepared MOF-derived double-layer hollow manganese silicate nanoparticle (DHMS) with highly effective ROS yield under ultrasound irradiation for multimodal imaging-guided sonodynamic therapy (SDT). The presence of Mn in DHMS increased ROS generation efficiency because it could be oxidized by holes to improve the electron-hole separation. Moreover, DHMS could produce oxygen in the tumor microenvironment, which helps overcome the hypoxia of the solid tumor and thus enhance the treatment efficiency. In vivo experiments demonstrated efficient tumor inhibition in DHMS-mediated SDT guided by ultrasound and magnetic resonance imaging. This work presents a MOF-derived nanoparticle with sonosensitive and oxygen generating ability, which provides a promising strategy for tumor hypoxia in SDT.