EFFECTS OF PSEUDOMONAS-AERUGINOSA COLONIZATION ON LUNG-FUNCTION AND ANTHROPOMETRIC VARIABLES IN CHILDREN WITH CYSTIC-FIBROSIS
EFFECTS OF PSEUDOMONAS-AERUGINOSA COLONIZATION ON LUNG-FUNCTION AND ANTHROPOMETRIC VARIABLES IN CHILDREN WITH CYSTIC-FIBROSIS
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DOI：
10.1002/ppul.1950190103
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发表时间：
1995-01-01
影响因子：
3.1
通讯作者：
BUCHDAHL, R
中科院分区：
文献类型：
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作者：
PAMUKCU, A;BUSH, A;BUCHDAHL, R
本研究的目的是评估与无铜绿假单胞菌的囊性纤维化（CF）儿童相比，铜绿假单胞菌定植的CF儿童的肺功能和生长随时间的变化。1982年至1992年期间，共有192名儿童参加了我们的囊性纤维化诊所。其中62人每年进行三次或三次以上肺功能评估，117人每年进行三次或三次以上身高和体重评估。当肺功能以标准差评分（SDS）表示时，与非定植儿童相比，定植儿童的1秒用力呼气量（FEV（1））和25%肺活量时用力呼气流量（FEF（25））在身高方面的下降幅度更大：FEV（1）-0.052 vs-0.015 SDS/cm FEF（25）分别为-0.060和-0.007SDS/cm（P < 0.05），用力肺活量（FVC）分别为-0.034和-0.012（NS）。在实际值中，Pa定殖的患者FEV（1）增加了16.4与31.6 mL/cm（P < 0.01）; FVC增加了28.8与41.4 mL/cm，P <0.01; FEF（25）增加了-0.001与0.015 L/s/cm，P < 0.01。在身高方面，定植儿童生长速度为5.63 cm/年vs 6.96 cm/年，P < 0.001，定植儿童与非定植儿童相比，身高SDS下降速度为-0.031 vs 0.08 SDS/年，P < 0.05。临床上，大多数CF儿童，无论是否有Pa，体重和身高的增长在标准值的+/- 1 SD内。然而，在肺功能方面，尽管有最佳的肺部管理，殖民儿童恶化显着更快。小儿肺醇。1995; 19：10-15. (C)1995 Wiley-Liss，Inc.
The aim of this study was to evaluate how lung function and growth changed over time in children with cystic fibrosis (CF) colonized with Pseudomonas aeruginosa (Pal compared with those free of the organism. A total of 192 children attended our cystic fibrosis clinic between 1982 and 1992. Sixty-two of these had three or more annual assessments for lung function, and 117 had three or more annual assessments for height and weight. When lung function was expressed as a standard deviation score (SDS), forced expiratory volume in 1 second (FEV(1)) and forced expiratory flow at 25% of vital capacity (FEF(25)) decreased significantly more with respect to height in colonized compared with noncolonized children: FEV(1) -0.052 versus -0.015 SDS/cm (P < 0.05); FEF(25), -0.060 versus -0.007 SDS/cm (P < 0.05); forced vital capacity (FVC), -0.034 versus -0.012 (NS). In actual values those patients colonized with Pa increased their FEV(1) by 16.4 versus 31.6 mL/cm (P < 0.01); FVC by 28.8 versus 41.4 mL/cm, P < 0,01; and FEF(25) by -0.001 versus 0.015 L/s/cm, P < 0.01. In terms of height, colonized children grew at 5.63 versus 6.96 cm/yr, P < 0.001, and height SDS decreased in colonized compared with noncolonized children at -0.031 versus 0.08 SDS/yr, P < 0.05. Clinically, most children with CF, with or without Pa, grew within +/- 1 SD of the norm for weight and height. However, in terms of lung function despite optimum pulmonary management colonized children deteriorated significantly faster. Pediatr Pulmonol. 1995; 19:10-15. (C) 1995 Wiley-Liss, Inc.