Prospective evaluation of fluorine-18 fluorodeoxyglucose positron emission tomography in breast cancer for staging of the axilla related to surgery and immunocytochemistry
Prospective evaluation of fluorine-18 fluorodeoxyglucose positron emission tomography in breast cancer for staging of the axilla related to surgery and immunocytochemistry
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DOI：
10.1007/bf01249621
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发表时间：
1996-12-01
期刊：
影响因子：
--
通讯作者：
Winter, PF
中科院分区：
文献类型：
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作者：
Utech, CI;Young, CS;Winter, PF
本文应用正电子发射断层显像（PET）对124例乳腺癌患者术前腋窝淋巴结转移进行了无创性分期。对124例初治乳腺癌患者进行了全身PET检查，测定了腋窝淋巴结的F-18-FDG平均差异摄取率（DUR）。结果与淋巴结清扫数目、原发肿瘤大小、肿瘤类型、肿瘤分级、雌激素和孕激素受体、DNA倍体和细胞周期合成期（S期）细胞比例相关。在124例乳腺癌患者的前瞻性研究中，PET正确分类了所有44个肿瘤阳性腋窝淋巴结，灵敏度为100%。60个肿瘤阴性腋窝淋巴结PET阴性，20个肿瘤阴性腋窝淋巴结PET阳性。未发现假阴性PET结果。DUR与肿瘤大小以及DUR与肿瘤的S期之间存在弱相关性。在乳腺癌患者中，F-18-FDG PET可在术前评估腋窝淋巴结转移的价值。特别重要的是，没有假阴性PET结果，腋窝淋巴结清扫术可能没有必要在患者腋窝PET摄取。阳性腋窝淋巴结的DUR似乎与原发肿瘤的一些预后参数有关。
The noninvasive staging of axillary lymph nodes for metastases is investigated in patients with breast cancer prior to surgery by positron emission tomography (PET) with fluorine-18-fluoro-2-deoxy-D-glucose (F-18-FDG), In 124 patients with newly diagnosed breast cancer, whole-body PET was performed to deter mine the average differential uptake ratio (DUR) of F-18-FDG in the axillary lymph nodes. Results were correlated with the number of the dissected lymph nodes, size of the primary tumor, tumor type, tumor grade, estrogen and progesterone receptors, DNA ploidy, and the propertion of cells in the synthetic phase of the cell cycle (S-phase). In this prospective study of 124 patients with breast carcinoma, PET correctly categorized all 44 tumor-positive axillary lymph nodes, a sensitivity of 100%. Sixty tumor-negative axillary lymph nodes were negative by PET and 20 tumor-negative axillary lymph nodes were positive by PET. No false-negative PET findings were encountered. A weak correlation was found between DUR and tumor size as well as between DUR and the S-phase of the tumor. In patients with breast carcinoma, F-18-FDG PET can be of value in evaluating axillary lymph nodes for metastatic involvement prior to surgery. It is of particular importance that no false-negative PET findings were encountered, and axillary lymph node dissection might not be necessary in patients without axillary uptake by PET. The DUR of the positive axillary lymph nodes seems to bear a relationship with some of the purported prognostic parameters of the primary tumor.