Diagnostic potential of T1ρ and T2 relaxations in assessing the severity of liver fibrosis and necro-inflammation
Diagnostic potential of T1ρ and T2 relaxations in assessing the severity of liver fibrosis and necro-inflammation
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DOI：
10.1016/j.mri.2022.01.002
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发表时间：
2022-01-13
影响因子：
2.5
通讯作者：
Ishigami, Kousei
中科院分区：
文献类型：
--
作者：
Takayama, Yukihisa;Nishie, Akihiro;Ishigami, Kousei
目的：探讨T1 rho和T2舒张在慢性肝病（CLD）患者肝纤维化（F期）和坏死-炎症（A期）严重程度评估中的作用。材料与方法：我们计算了82例肝脏手术患者肝实质的T1、p和T2弛豫。通过参考手术切除的标本来评估入组患者的F期和A期。采用单向方差分析评估T1 rho或T2松弛与F或A期之间的关系，随后采用Tukey多重比较检验、Spearman秩相关检验和患者工作特征分析。结果：肝实质T1 rho、T2值随F期、A期进展明显增高。T1 rho和T2值在F0与F4、F1与F4、F2与F4之间存在显著差异。此外，T1 rho值在F0和F3之间也有显著差异。鉴别>= F3与= A1与A0时，对纤维化的诊断能力最高。结论：T1 rho和T2舒张可作为评价肝纤维化和necm炎症严重程度的生化指标。在肝纤维化和坏死炎症的诊断能力方面，T1 rho松弛可能略优于T2松弛。
Purpose: To investigate the utility of T1 rho and T2 relaxations for assessing the severity of liver fibrosis (F stage) and necro-inflammation (A stage) in patients with chronic liver disease (CLD).Materials and methods: We calculated T1 p and T2 relaxations of the liver parenchyma in 82 patients who underwent liver surgery. F and A stages of enrolled patients were assessed by referring to surgically resected specimens. The relationships between T1 rho or T2 relaxation and F or A stage were assessed using one-way analysis of variance followed by Tukey's multiple comparison test, Spearman's rank correlation test and a receiver operating characteristic analysis.Results: The T1 rho and T2 values of the liver parenchyma were significantly increased as the F and A stages progressed. The T1 rho and T2 values showed significant differences between F0 and F4, between F1 and F4, and between F2 and F4. In addition, T1 rho values showed a significant difference between F0 and F3 as well. The highest diagnostic ability for fibrosis was obtained when differentiating >= F3 from = A1 from A0.Conclusion: T1 rho and T2 relaxations have potential as a biochemical marker for assessing the severity of liver fibrosis and necm-inflammation. T1 rho relaxation may be slightly superior to T2 relaxation in terms of diagnostic ability for liver fibrosis and necro-inflammation.