Biodegradable Nanoagents with Short Biological Half-Life for SPECT/PAI/MRI Multimodality Imaging and PTT Therapy of Tumors
Biodegradable Nanoagents with Short Biological Half-Life for SPECT/PAI/MRI Multimodality Imaging and PTT Therapy of Tumors
复制标题
用于 SPECT/PAI/MRI 多模态成像和肿瘤 PTT 治疗的生物半衰期短的可生物降解纳米制剂。
DOI：
10.1002/smll.201702700
复制
发表时间：
2018-01-25
期刊：
影响因子：
13.3
通讯作者：
Gao, Mingyuan
中科院分区：
文献类型：
--
作者：
Chen, Lei;Chen, Jiayao;Gao, Mingyuan
纳米制剂的快速清除是其临床转化的关键标准。在此，据报道，生物可降解和肾可清除的纳米粒子是潜在的用于肿瘤的图像引导光热治疗。通过Fe 3+离子与没食子酸（GA）/聚乙烯吡咯烷酮（PVP）在水溶液中的配位反应，合成了具有良好胶体稳定性的多功能纳米粒子。详细的表征表明，所得到的Fe 3 +/GA/PVP复合纳米粒子（FGPNs）集成了强的近红外吸收和顺磁性良好。因此，FGPNs表现出优异的性能，用于肿瘤的光声成像和磁共振成像，以及由于其高光热转换效率而表现出优异的光热消融效应用于肿瘤治疗。更重要的是，通过I-125标记确定的FGPNs的药代动力学行为表明，FGPNs在体内易于降解，显示出较短的生物半衰期，并且分解产物通过肾脏清除途径或经胃的肠消除途径排泄，这突出了当前多功能治疗诊断剂的特征及其在临床转化中的潜力。
Rapid clearance of nanoagents is a critical criterion for their clinical translation. Herein, it is reported that biodegradable and renal clearable nanoparticles are potentially useful for image-guided photothermal therapy of tumors. The multifunctional nanoparticles with excellent colloidal stability are synthesized through coordination reactions between Fe3+ ions and gallic acid (GA)/polyvinyl pyrrolidone (PVP) in aqueous solution. Detailed characterization reveals that the resulting Fe3+/GA/PVP complex nanoparticles (FGPNs) integrate strong near-infrared absorption with paramagnetism well. As a result, the FGPNs present outstanding performance for photoacoustic imaging and magnetic resonance imaging of tumors, and outstanding photothermal ablation effect for tumor therapy owing to their high photothermal conversion efficiency. More importantly, the pharmacokinetic behaviors of the FGPNs determined through I-125 labeling suggest that the FGPNs are readily degraded in vivo showing a short biological half-life, and the decomposition products are excreted through either renal clearance pathway or bowel elimination pathway via stomach, which highlights the characteristics of the current multifunctional theranostic agent and their potential in clinical translation.