Expression patterns of plexins and neuropilins are consistent with cooperative and separate functions during neural development.
Expression patterns of plexins and neuropilins are consistent with cooperative and separate functions during neural development.
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DOI：
10.1186/1471-213x-6-32
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发表时间：
2006-07-17
影响因子：
--
通讯作者：
Stoeckli ET
中科院分区：
文献类型：
--
作者：
Mauti O;Sadhu R;Gemayel J;Gesemann M;Stoeckli ET
丛蛋白是一个跨膜蛋白家族，被证明可以单独或与神经磷脂复合物一起作为信号蛋白的受体。根据结构标准丛状蛋白被细分为A ~ d 4类。丛状蛋白主要被认为在细胞迁移和轴突引导中作为排斥信号的介质。它们在脊椎动物中的功能作用几乎完全是在信号蛋白信号的背景下研究的，即作为3类信号蛋白的共受体。对其他三类的丛状蛋白知之甚少。尽管丛蛋白参与神经元回路的形成，但其表达模式在神经系统发育过程中的时间变化尚未得到详细分析。在鸡的基因组中只发现了7个丛状蛋白，而在哺乳动物基因组中发现了9个丛状蛋白。在这里，我们描述了所有已知丛蛋白家族成员的动态表达模式，并与发育中的鸡脊髓中的神经磷脂进行了比较。我们的原位杂交研究表明，神经丛蛋白和神经柱蛋白的表达模式仅部分重叠，特别是在脊髓发育的早期和中期，支持神经丛蛋白和神经柱蛋白在神经回路形成中的合作和分离功能。
Plexins are a family of transmembrane proteins that were shown to act as receptors for Semaphorins either alone or in a complex together with Neuropilins. Based on structural criteria Plexins were subdivided into 4 classes, A through D. PlexinAs are mainly thought to act as mediators of repulsive signals in cell migration and axon guidance. Their functional role in vertebrates has been studied almost exclusively in the context of Semaphorin signaling, i.e. as co-receptors for class 3 Semaphorins. Much less is known about Plexins of the other three classes. Despite the fact that Plexins are involved in the formation of neuronal circuits, the temporal changes of their expression patterns during development of the nervous system have not been analyzed in detail. Only seven plexins are found in the chicken genome in contrast to mammals, where nine plexins have been identified. Here, we describe the dynamic expression patterns of all known plexin family members in comparison to the neuropilins in the developing chicken spinal cord. Our in situ hybridization study revealed that the expression patterns of plexins and neuropilins are only partially overlapping, especially during early and intermediate stages of spinal cord development, supporting both cooperative and separate functions of plexins and neuropilins in neural circuit formation.