NMDA receptor mRNA correlation with antemortem cognitive impairment in schizophrenia
NMDA receptor mRNA correlation with antemortem cognitive impairment in schizophrenia
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DOI：
10.1097/00001756-199608120-00040
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发表时间：
1996-08-12
期刊：
影响因子：
1.7
通讯作者：
deBelleroche, J
中科院分区：
文献类型：
--
作者：
Humphries, C;Mortimer, A;deBelleroche, J
我们研究了n -甲基- d -天冬氨酸（NMDA）受体的表达，这是一种重要的谷氨酸受体，来自一群具有良好特征的精神分裂症患者的大脑，他们前瞻性地同意组织捐赠。认知障碍精神分裂症患者颞叶上皮层组织匀浆中NR-1 mRNA的水平与对照组相比降低了30% (p < 0.04)，而无认知障碍患者的水平则没有这种降低。NR-1 mRNA缺失与总体恶化量表评定的一般认知功能（p < 0.001）、迷你精神状态检查（p < 0.01）和全国成人阅读测试（NART）测定的病前智商（p < 0.01）显著相关。单独分析或合并分析时，对照组和精神分裂症组的NR-1 mRNA浓度与年龄、性别、pH值或死后延迟无关。因此，在精神分裂症患者中，NR-1 mRNA丢失与认知能力下降之间存在显著相关性。
WE investigated the expression of the N-methyl-D-aspartate (NMDA) receptor, an important glutamate receptor, in brains from a population of well characterized schizophrenic patients who prospectively consented to tissue donation. Levels of NR-1 mRNA in tissue homogenates of superior temporal cortex were reduced by 30% in cognitively impaired schizophrenic patients compared with controls (p < 0.04), while levels in patients without cognitive impairment showed no such reduction. The NR-1 mRNA deficit was significantly correlated with general cognitive function as rated with the Global Deterioration scale (p < 0.001), the Mini-Mental State examination (p < 0.01) and the premorbid IQ determined using the National Adult Reading Test (NART, p < 0.01). NR-1 mRNA concentration was not correlated with age, sex, pH or postmortem delay in the control and schizophrenia group when analysed separately or combined. There was, therefore, a significant correlation between NR-1 mRNA loss and cognitive deterioration in patients with schizophrenia.