Association Between Nutritional Status, Inflammatory Condition, and Prognostic Indexes with Postoperative Complications and Clinical Outcome of Patients with Gastrointestinal Neoplasia
Association Between Nutritional Status, Inflammatory Condition, and Prognostic Indexes with Postoperative Complications and Clinical Outcome of Patients with Gastrointestinal Neoplasia
复制标题
DOI：
10.1080/01635581.2016.1206578
复制
发表时间：
2016-01-01
影响因子：
2.9
通讯作者：
Oliveira dos Santos, Ana Celia
中科院分区：
文献类型：
--
作者：
de Souza Costa, Milena Damasceno;Sousa Vieira de Melo, Camila Yandara;Oliveira dos Santos, Ana Celia
本研究的目的是描述胃肠道恶性肿瘤患者的营养和炎症状态以及预后指标与术后并发症和临床结局之间的关系。对29例患者进行了评价;通过主观和客观参数进行营养评估;测定白蛋白、前白蛋白、C反应蛋白（CRP）和α-1-酸性糖蛋白（AGP）。为了评估预后，使用了格拉斯哥量表、预后炎症营养指数（PINI）和CRP/白蛋白比值;考虑的临床结局为出院和死亡。主观综合评价（SGA）评分高与术后并发症的发生相关：73%的术后并发症患者SGA评分最高，但只有6%的无术后并发症患者SGA评分最高（P < 0.001）。在SGA评分高、血清白蛋白低、CRP升高、PINI > 1和格拉斯哥评分2的患者中观察到死亡发生率较高。体重减轻百分比与血清CRP水平（P = 0.002）、CRP/白蛋白（P = 0.002）、PINI（P = 0.002）和格拉斯哥评分（P = 0.000）呈正相关。这项研究提供的证据表明，营养状况的评估和预后指标的使用是很好的工具，预测术后并发症和临床结果的胃肠道肿瘤患者。
The aim of this study is to describe and relate nutritional and inflammatory status and prognostic indexes with postoperative complications and clinical outcome of patients with gastrointestinal malignancies. Twenty-nine patients were evaluated; nutritional assessment was carried out by subjective and objective parameters; albumin, pre-albumin, C-reactive protein (CRP), and alpha-1-acid glycoprotein (AGP) were determined. To assess prognosis, the Glasgow scale, the Prognostic Inflammatory Nutritional Index (PINI), and CRP/albumin ratio were used; the clinical outcomes considered were hospital discharge and death. A high Subjective Global Assessment (SGA) score was associated with the occurrence of postoperative complications: 73% of the patients with postoperative complications had the highest SGA score, but only 6% of those without postoperative complications had the highest SGA score (P < 0.001). Greater occurrence of death was observed in patients with a high SGA score, low serum albumin, increased CRP, PINI > 1, and Glasgow score 2. There was a positive correlation between weight loss percentage with serum CRP levels (P = 0.002), CRP/albumin (P = 0.002), PINI (P = 0.002), and Glasgow score (P = 0.000). This study provides evidence that the assessment of the nutritional status and the use of prognostic indexes are good tools for predicting postoperative complications and clinical outcome in patients with gastrointestinal neoplasia.