Role of antibody signaling in inducing tumor dormancy.
Role of antibody signaling in inducing tumor dormancy.
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抗体信号传导在诱导肿瘤休眠中的作用。
DOI：
10.1007/978-1-4899-0274-0_7
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发表时间：
1996
影响因子：
--
通讯作者：
Scheuermann,RH
中科院分区：
文献类型：
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作者：
Uhr,JW;Marches,R;Racila,E;Tucker,TF;Hsueh,R;Street,NE;Vitetta,ES;Scheuermann,RH
癌症休眠是一种公认的临床现象，其中存在肿瘤细胞，但肿瘤负荷不会长时间增加1 -3。然而，肿瘤细胞可以在多年后重新生长。在乳腺癌中，原发肿瘤切除后10至20年的复发率稳定13，4，复发肿瘤通常以快速的速度生长（5）。一个特别相关的例子是低级别（滤泡）形式的非霍奇金淋巴瘤（NHL），其中长期缓解是常见的，但最终，几乎所有人都死于复发。Levy和米勒（5）用单克隆抗独特型（Id）治疗了这类患者，并在很大比例的患者中实现了缓解。复发（许多由Id阴性变体引起）是频繁的，表明抗体（Ab）在诱导携带相应独特表位的细胞中的休眠方面特别有效，但是VHand VL基因的超突变最终允许来自原始克隆的一些肿瘤细胞逃逸（5-7）。
Cancer dormancy is a well-recognized clinical phenomenon in which tumor cells are present, but the tumor burden does not increase for long periods of time1–3. However, tumor cells can regrow many years later. In breast cancer, there is a steady rate of recurrence 10 to 20 years after removal of the primary tumorl3,4and the recurrent tumor frequently grows at a rapid rate(5). A particularly pertinent example is the low grade (follicular) form of non-Hodgkin’s lymphoma (NHL) in which long-term remissions are common but, eventually, virtually all die of a recurrence. Levy and Miller(5)have treated such patients with monoclonal anti-idiotype (Id) and have achieved remissions in a high proportion of patients. Relapses, many caused by Id-negative variants, are frequent indicating that the antibody (Ab) was particularly effective in inducing dormancy in cells bearing the corresponding idiotope but that hypermutation of VHand VLgenes eventually allow some tumor cells from the original clone to escape(5–7).