Refractive errors, axial ocular dimensions, and age-related cataracts: the Tanjong Pagar survey.
Refractive errors, axial ocular dimensions, and age-related cataracts: the Tanjong Pagar survey.
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DOI：
10.1167/iovs.02-0526
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发表时间：
2003-04
影响因子：
4.4
通讯作者：
T. Wong;P. Foster;G. Johnson;S. Seah
中科院分区：
文献类型：
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作者：
T. Wong;P. Foster;G. Johnson;S. Seah
目的探讨屈光不正、眼轴与年龄相关性白内障的关系。方法：对居住在新加坡丹戎巴葛地区的40 ~ 81岁的中国男性和女性（n = 1232）进行以人群为基础的眼科疾病横断面调查。作为检查的一部分，使用自动验光仪测定屈光度和角膜曲率，并进一步主观完善屈光度。用A型超声设备测量眼轴长度、前房深度、透镜厚度和玻璃体腔深度等眼部尺寸。根据透镜混浊分类系统（LOCS）III系统对透镜混浊进行临床分级。分别分析右眼（n = 989）和左眼（n = 995）的屈光、生物测量和白内障数据。结果在控制了年龄、性别、教育、糖尿病和吸烟的分析中，核性白内障与近视相关（-1.35 D vs. -0.11 D，P < 0.001，比较右眼有无核性白内障），但与任何特定的生物特征成分无关。皮质性白内障与较薄的晶状体相关（4.67 mm vs. 4.79 mm，P = 0.001，比较有和无皮质性白内障的右眼），但与屈光和其他生物特征成分无关。后囊下白内障与近视相关（-1.80 D vs. -0.39 D，P < 0.001，比较有和无后囊下白内障的右眼），深前房（3.00 mm vs. 2.89 mm，P = 0.02），更薄的透镜（4.62 mm vs. 4.77 mm，P = 0.001）和较长的玻璃体腔（15.78 mm vs. 15.57 mm，P = 0.09），但与总眼轴长度和角膜曲率无关。调整玻璃体腔深度可使后囊下白内障与近视的相关性降低65.5%，但对核性白内障与近视的相关性无明显影响。结论：这些以人群为基础的数据支持先前研究中报道的核性和后囊下白内障与近视之间的相关性。后囊下白内障还与更深的前房、更薄的透镜和更长的玻璃体腔相关，玻璃体腔深度解释了后囊下白内障与近视之间的大部分关联。
PURPOSE To describe the relationship of refractive errors and axial ocular dimensions and age-related cataract. METHODS Population-based, cross-sectional survey of ocular diseases among Chinese men and women aged 40 to 81 years (n = 1232) living in the Tanjong Pagar district in Singapore. As part of the examination, refraction and corneal curvature were determined with an autorefractor, with refraction further refined subjectively. Ocular dimensions, including axial length, anterior chamber depth, lens thickness, and vitreous chamber depth, were measured with an A-mode ultrasound device. Lens opacity was graded clinically according to the Lens Opacity Classification System (LOCS) III system. Refraction, biometry, and cataract data on right (n = 989) and left (n = 995) eyes were analyzed separately. RESULTS In analyses controlling for age, gender, education, diabetes, and cigarette smoking, nuclear cataract was associated with myopia (-1.35 D vs. -0.11 D, P < 0.001, comparing right eyes with and without nuclear cataract), but not with any specific biometric component. Cortical cataract was associated with thinner lenses (4.67 mm vs. 4.79 mm, P = 0.001, comparing right eyes with and without cortical cataract), but not with refraction and other biometric components. Posterior subcapsular cataract was associated with myopia (-1.80 D vs. -0.39 D, P < 0.001, comparing right eyes with and without posterior subcapsular cataract), deeper anterior chamber (3.00 mm vs. 2.89 mm, P = 0.02), thinner lens (4.62 mm vs. 4.77 mm, P = 0.001), and longer vitreous chamber (15.78 mm vs. 15.57 mm, P = 0.09), but not with overall axial length and corneal curvature. Adjustment for vitreous chamber depth attenuated the association between posterior subcapsular cataract and myopia by 65.5%, but did not substantially change the association between nuclear cataract and myopia. CONCLUSIONS These population-based data support the associations between nuclear and posterior subcapsular cataracts and myopia reported in previous studies. Posterior subcapsular cataract is also associated with deeper anterior chamber, thinner lens, and longer vitreous chamber, with vitreous chamber depth explaining most of the association between posterior subcapsular cataract and myopia.