INTERLEUKIN-1 STIMULATES THE SECRETION OF HYPOTHALAMIC CORTICOTROPIN-RELEASING FACTOR
INTERLEUKIN-1 STIMULATES THE SECRETION OF HYPOTHALAMIC CORTICOTROPIN-RELEASING FACTOR
复制标题
DOI：
10.1126/science.2821621
复制
发表时间：
1987-10-23
期刊：
影响因子：
56.9
通讯作者：
VALE, W
中科院分区：
文献类型：
--
作者：
SAPOLSKY, R;RIVIER, C;VALE, W
现在有证据表明，免疫系统在受到感染时，可以刺激糖皮质激素的分泌，这是一种肾上腺类固醇，在应激反应的重要方面起调节作用。具体来说，白细胞介素-1 （IL-1）的分泌，感染后分泌的单核细胞淋巴因子，似乎至少部分负责这种效果。糖皮质激素的分泌是对神经内分泌级联反应的反应，首先涉及大脑，然后是垂体，最后是肾上腺。在这份报告中，人类IL-1被证明在大脑水平上激活肾上腺皮质轴，刺激从下丘脑释放控制激素促肾上腺皮质激素释放因子（CRF）。输注IL-1诱导大量的CRF分泌到下丘脑的循环中，而CRF的免疫中和则阻断了IL-1对糖皮质激素分泌的刺激作用。IL-1似乎对该系统的垂体或肾上腺成分没有急性直接刺激作用。此外，IL-1不会引起其他下丘脑激素的非特异性释放。因此，淋巴因子以特定的方式在脑水平上激活肾上腺皮质轴；这种作用似乎与已知的下丘脑内IL-1的热原作用无关。
There is now evidence that the immune system, during times of infectious challenge, can stimulate the secretion of glucocorticoids, the adrenal steroids that mediate important aspects of the response to stress. Specifically, secretion of interleukin-1 (IL-1), a monocyte lymphokine secreted after infection, appears at least in part responsible for this effect. Glucocorticoids are secreted in response to a neuroendocrine cascade involving, first, the brain, then the pituitary, and finally the adrenal gland. In this report, human IL-1 is shown to activate the adrenocortical axis at the level of the brain, stimulating the release of the controlling hormone corticotropin-releasing factor (CRF) from the hypothalamus. Infusion of IL-1 induced a significant secretion of CRF into the circulation exiting the hypothalamus, whereas immunoneutralization of CRF blocked the stimulatory effect of IL-1 on glucocorticoid secretion. IL-1 appeared to have no acute direct stimulatory effects on the pituitary or adrenal components of this system. Furthermore, IL-1 did not cause a nonspecific release of other hypothalamic hormones. Thus, the lymphokine acts in a specific manner to activate the adrenocortical axis at the level of the brain; this effect appears to be unrelated to the known pyrogenic effects of IL-1 within the hypothalamus.