Brain areas involved in interlimb coordination:: A distributed network
Brain areas involved in interlimb coordination:: A distributed network
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DOI：
10.1006/nimg.2001.0892
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发表时间：
2001-11-01
期刊：
影响因子：
5.7
通讯作者：
Duysens, J
中科院分区：
文献类型：
--
作者：
Debaere, F;Swinnen, SP;Duysens, J
虽然行为学研究在确定控制肢体运动协调的原则方面做出了重大贡献，但对参与肢体间协调的高级大脑区域所起的作用知之甚少。用功能磁共振成像(FMRI)显示同侧手腕和足部运动的周期性协调过程中激活的脑区。6名正常受试者按随机顺序完成了5种不同的任务，即右腕(腕)和右脚(足)的独立屈伸运动，按等向(ISODIR)和非等向(Non-ISODIR)模式进行的腕足循环协调，以及休息(Rest)。所有动作均以66次/分钟的频率进行听觉起搏。在两个肢体节段的协调过程中，发现了一个分布的网络，显示辅助运动区(SMA)、扣带运动皮质(CMC)、运动前皮质(PMC)、初级感觉运动皮质(M1/S1)和小脑的激活水平超过了单独肢体运动时观察到的激活水平的总和。此外，与同一方向的运动相比，肢体在不同方向的运动协调与SMA的额外激活有关。因此，我们得出结论，作为分布式运动网络的一部分，SMA实质上参与了非同源肢体的协调。因此，这个额叶内侧区域和双手(同源)协调之间长期存在的排他性联系需要被摒弃，并扩展到其他形式的肢体间协调(非同源)。(C)2001年学术出版社。
Whereas behavioral studies have made significant contributions toward the identification of the principles governing the coordination of limb movements, little is known about the role of higher brain areas that are involved in interlimb coordination. Functional magnetic resonance imaging (fMRI) was used to reveal the brain areas activated during the cyclical coordination of ipsilateral wrist and foot movements. Six normal subjects performed five different tasks that were presented in a random order, i.e., isolated flexion-extension movements of the right wrist (WRIST) and right foot (FOOT), cyclical coordination of wrist and foot according to the isodirectional (ISODIR) and nonisodirectional (NON-ISODIR) mode, and rest (REST). All movements were auditory paced at 66 beats/min. During the coordination of both limb segments, a distributed network was identified showing activation levels in the supplementary motor area (SMA), cingulate motor cortex (CMC), premotor cortex (PMC), primary sensorimotor cortex (M1/S1), and cerebellum that exceeded the sum of the activations observed during the isolated limb movements. In addition, coordination of the limb movements in different directions was associated with extra activation of the SMA as compared to movements in the same direction. It is therefore concluded that the SMA is substantially involved in the coordination of the nonhomologous limbs as part of a distributed motor network. Accordingly, the long-standing exclusive association that has been made between this medial frontal area and bimanual (homologous) coordination needs to be abandoned and extended towards other forms of interlimb coordination (nonhomologous). (C) 2001 Academic Press.