SECRETION OF PARATHYROID-HORMONE BY ABNORMAL HUMAN PARATHYROID-GLANDS INVITRO
SECRETION OF PARATHYROID-HORMONE BY ABNORMAL HUMAN PARATHYROID-GLANDS INVITRO
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DOI：
10.1210/jcem-45-1-105
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发表时间：
1977-01-01
影响因子：
5.8
通讯作者：
SHERWOOD, LM
中科院分区：
文献类型：
--
作者：
BIRNBAUMER, ME;SCHNEIDER, AB;SHERWOOD, LM
本文对11例原发性和继发性甲状旁腺功能亢进患者手术获得的异常甲状旁腺的分泌反应进行了体外观察。短期烧瓶研究用于测量高钙（3.0 mM）和低钙（0.5 mM）时甲状旁腺激素（PTH）的释放。在8个腺瘤中，除1个外，所有腺瘤在暴露于低钙（对钙有反应）时均显示激素释放增加，3小时的刺激程度为15-209%。相比之下，2个正常人的腺体受到平均180%的刺激。3例继发性增生患者的腺体也对Ca有反应。原发性和继发性甲状旁腺功能亢进症患者的甲状旁腺对Ca有一系列反应，绝对自主不常见。即使在高钙浓度下，激素释放持续在低但确定的水平（基底分泌）。甲状旁腺功能细胞的总数是甲状旁腺功能亢进患者甲状旁腺激素过度分泌的主要决定因素。
The secretory response of abnormal parathyroid glands obtained surgically from 11 patients with primary and secondary hyperparathyroidism was tested in vitro. Short term flask studies were used to measure release of parathyroid hormone (PTH) at high (3.0 mM) and low (0.5 mM) Ca. Of 8 adenomas, all but one showed increased release of hormone when exposed to low Ca (responsive to Ca), the degree of stimulation at 3 h ranging 15-209%. By comparison, 2 normal human glands were stimulated an average of 180%. Glands from 3 patients with secondary hyperplasia were also responsive to Ca. Parathyroid glands from patients with primary and secondary hyperparathyroidism were characterized by a spectrum of responsiveness to Ca, and absolute autonomy was unusual. Even at high Ca concentrations, hormone release persisted at a low but definite level (basal secretion). The total number of functioning parathyroid cells is a principal determinant in the oversecretion of PTH in hyperparathyroidism.