Epithelial cell responses
Epithelial cell responses
复制标题
DOI：
10.1053/ybega.2004.438
复制
发表时间：
2004-04-01
影响因子：
3.2
通讯作者：
Mahida, YR
中科院分区：
文献类型：
--
作者：
Mahida, YR
肠上皮细胞是独特的，因为它们代表了唯一的宿主细胞，不断与管腔中非常大的细菌群体相互作用。单层上皮细胞由具有不同功能的亚群组成，包括保护免受管腔微生物的侵害。虽然微生物植物群仍有待充分表征，但其与宿主肠上皮细胞的正常关系似乎主要是共生或共生的。上皮-微生物关系的分子复杂性已在检查无菌小鼠中常驻细菌的建立的研究中显示。最近的工作也证明了常驻细菌增强上皮保护反应的能力。上皮细胞可能避免对驻留微生物的促炎反应，同时保留对病原体反应的能力的机制也正在被表征。
Intestinal epithelial cells are unique in that they represent the only host cells that are constantly interacting with a very large bacterial population in the lumen. The single monolayer of epithelial cells consists of subpopulations with distinct functions that include protection against luminal microorganisms. Although the microbial flora remains to be fully characterized, its normal relationship with the host intestinal epithelial cells appears to be predominantly symbiotic or commensal. The molecular complexity of the epithelial-microbial relationship has been shown in studies that have examined the establishment of the resident bacteria in germ-free mice. Recent work has also demonstrated the ability of resident bacteria to enhance epithelial protective responses. The mechanisms by which epithelial cells may avoid pro-inflammatory responses to resident microorganisms, while retaining the capacity to respond to pathogens, are also being characterized.