Intra- and interindividual variation in measurements of beta-carotene, retinol, and tocopherols in diet and plasma.
Intra- and interindividual variation in measurements of beta-carotene, retinol, and tocopherols in diet and plasma.
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饮食和血浆中β-胡萝卜素、视黄醇和生育酚测量值的个体内和个体间差异。
DOI：
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发表时间：
1987
影响因子：
7.1
通讯作者：
E. P. Betz
中科院分区：
文献类型：
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作者：
C. Tangney;R. Shekelle;W. Raynor;M. Gale;E. P. Betz
对24名男性进行了为期4周的研究，以评估饮食和血浆中视黄醇、β-胡萝卜素和生育酚的个体内和个体间差异。个体内和个体间的差异比率从血浆中的β-胡萝卜素的0.62到饮食中的维生素E的6.02不等。结果表明，可能需要3-9个独立的测量来可靠地区分这些微量营养素中的大差异(大约1 SD)；对于小的差异(大约0.25 SD)，可能需要28-86个独立的测量。如果不加以控制，个体内和个体间的大比例差异可能会成为微量营养素研究中的一个重要误差来源。
Twenty-four men were studied for 4 wk to estimate intra- and interindividual variation of retinol, beta-carotene, and tocopherols in diet and plasma. Ratios of intra- to interindividual variances ranged from 0.62 for beta-carotene in plasma to 6.02 for vitamin E in diet. Results indicate that 3-9 independent measurements may be required to distinguish reliably even large differences (approximately 1 SD) in these micronutrients; 28-86 independent measurements may be needed for small differences (approximately 0.25 SD). If uncontrolled, large ratios of intra- to interindividual variance can constitute an important source of error in studies of micronutrients.