Centralized HIV-1 envelope immunogens and neutralizing antibodies
Centralized HIV-1 envelope immunogens and neutralizing antibodies
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DOI：
10.2174/157016207782418498
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发表时间：
2007-11-01
影响因子：
1
通讯作者：
Haynes, Barton F.
中科院分区：
文献类型：
--
作者：
Gao, Feng;Liao, Hua-Xin;Haynes, Barton F.
最近，人们探索了集中的HIV-1基因（共识、最近的共同祖先和树的中心），以诱导广泛反应性免疫反应，以克服HIV-1毒株之间非凡的遗传多样性。虽然所有这些策略都是基于计算机程序预测的人工序列，但它们保留了生物学功能，并使用CCR 5辅助受体作为HIV-1 Env进入靶细胞。来自实验室动物的结果表明，集中的免疫原上级许多野生型免疫原，用于诱导交叉亚型T和B细胞免疫应答。结构修饰提高了共有Env引发中和HIV-1 Env假病毒谱的抗体应答的能力。然而，更难中和的2级Env假病毒通常不能被抗共有Env抗体很好地中和，这表明需要进一步的修饰、新的制剂或额外的策略来产生中和全谱传播的HIV-1毒株的抗体。
Centralized HIV-1 genes (consensus, most recent common ancestor and center of the tree) have recently been explored for induction of broadly reactive immune responses to overcome the extraordinary genetic diversity among HIV-1 strains. Although all of these strategies are based on artificial sequences predicted by computer programs, they retain biological function, and use the CCR5 co-receptor for entry into target cells as transmitted HIV-1 Envs. Results from laboratory animals indicate that centralized immunogens are superior to many wild-type immunogens for inducing cross-subtype T and B cell immune responses. Structural modifications have improved the ability of consensus Envs to elicit antibody responses that neutralize a spectrum of HIV-1 Env pseudoviruses. However, the more difficult to neutralize tier 2 Env pseudoviruses are generally not neutralized well by anti-consensus Env antibodies, indicating the need for further modifications, new formulations, or additional strategies to generate antibodies that neutralize a full spectrum of transmitted HIV-1 strains.