Opioid receptor involvement in the adaptation to motion sickness in Suncus murinus
Opioid receptor involvement in the adaptation to motion sickness in Suncus murinus
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DOI：
10.1016/s0091-3057(01)00470-1
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发表时间：
2001-04-01
影响因子：
3.6
通讯作者：
Naylor, RJ
中科院分区：
文献类型：
--
作者：
Javid, FA;Naylor, RJ
本研究的目的是探讨阿片受体参与运动病的适应性反应，在臭鼩 鼱。不同组的动物在不存在或在1Hz和40 mm幅度的水平运动刺激之前30 min腹膜内用盐水、吗啡（0.1和1.0 mg/kg）、纳洛酮（1.0、10.0和5.0 mg/kg）或纳洛酮加吗啡的组合处理。对于适应性研究，不同的组在第一次试验中接受生理盐水，在随后的试验中（每2天一次），他们接受生理盐水。纳洛酮（1.0和10.0 mg/kg. ip）或吗啡（0.1mg/kg，ip）。用吗啡预处理引起了剂量相关的减少呕吐引起的一个单一的挑战运动刺激。单独使用纳洛酮预处理本身不会引起呕吐，也不会改变由单一运动刺激引起的呕吐。而纳洛酮（5.0mg/kg，ip）预处理则显示对吗啡的呕吐反应（P
The aim of the present study was to investigate an opioid receptor involvement in the adaptation response to motion sickness in Suncus murinus. Different groups of animals were treated intraperitoneally with either saline, morphine (0.1 and 1.0 mg/kg), naloxone (1.0, 10.0 and 5.0 mg/kg) or a combination of naloxone plus morphine in the absence or 30 min prior to a horizontal motion stimulus of 1 Hz and 40 mm amplitude. For the study of adaptation, different groups received saline on the first trial, and in subsequent trials (every 2 days) they received either saline. naloxone (1.0 and 10.0 mg/kg. ip) or morphine (0.1 mg/kg, ip) 30 min prior to the motion stimulus. Pretreatment with morphine caused a dose-related reduction in emesis induced by a single challenge to a motion stimulus. Pretreatment with naloxone alone did not induce emesis in its own right nor did it modify emesis induced by a single challenge to a motion stimulus. However, pretreatment with naloxone (5.0 mg/kg, ip) revealed an emetic response to morphine (P